| Type |
Mechanism |
Example
|
| I: Allergy, Immediate |
IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization |
Urticaria, anaphylaxis, angioedema
|
| II: Cytotoxic, Antibody Dependant |
IgG or IgM antibodies react with cell antigens with resultant complement activation |
Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease
|
| III: Immune Complex |
IgG immune complex deposition and subsequent complement activation |
Serum sickness, RA, SLE, poststreptococcal glomerulonephritis
|
| IV: Cell-mediated, Delayed |
Activated T cells against cell surface antigens |
TB skin test, chronic transplant rejection, delayed drug rashes, contact dermatitis
|
