Difference between revisions of "Hypersensitivity reaction"

(Clinical Features)
Line 13: Line 13:
 
| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[post-strep glomerularnephritis]]
 
| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[post-strep glomerularnephritis]]
 
|-
 
|-
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, contact dermatitis
+
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, [[contact dermatitis]]
 
|}
 
|}
  

Revision as of 04:08, 21 October 2015

Background

  • Uncomfortable, damaging, and sometimes fatal reactions produced by the normal immune system including allergies and autoimmunity.

Clinical Features

Type Mechanism Example
I: Allergy, Immediate IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization Urticaria, anaphylaxis, angioedema
II: Cytotoxic, Antibody Dependant IgG or IgM antibodies react with cell antigens with resultant complement activation Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease
III: Immune Complex IgG immune complex deposition and subsequent complement activation Serum sickness, RA, SLE, post-strep glomerularnephritis
IV: Cell-mediated, Delayed Activated T cells against cell surface antigens TB skin test, chronic transplant rejection, contact dermatitis

See Also

References