Difference between revisions of "Hypersensitivity reaction"

(Hypersensitivity)
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! Type !! Mechanism !! Example
 
! Type !! Mechanism !! Example
 
|-
 
|-
| I: Allergy, Immediate || IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization || Urticaria, anaphylaxis, angioedema
+
| I: Allergy, Immediate || IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization || [[Urticaria]], [[anaphylaxis]], [[angioedema]]
 
|-
 
|-
| II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease
+
| II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || [[Myasthenia gravis]], [[goodpasture syndrome]], erythroblastalis fetalis, AI hemolytic anemia, Graves disease
 
|-
 
|-
| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || Serum sickness, RA, SLE, post-strep glomerularnephritis
+
| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[post-strep glomerularnephritis]]
 
|-
 
|-
 
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, contact dermatitis
 
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, contact dermatitis
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==See Also==
 
==See Also==
 
*[[Acute allergic reaction]]
 
*[[Acute allergic reaction]]
*[[Anaphylaxis]]
 
*[[Angioedema]]
 
*[[Lupus]]
 
*[[Serum Sickness]]
 
 
*[[Contact dermatitis]]
 
*[[Contact dermatitis]]
 +
 
==References==
 
==References==
 
<references/>
 
<references/>

Revision as of 04:08, 21 October 2015

Background

  • Uncomfortable, damaging, and sometimes fatal reactions produced by the normal immune system including allergies and autoimmunity.

Clinical Features

Type Mechanism Example
I: Allergy, Immediate IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization Urticaria, anaphylaxis, angioedema
II: Cytotoxic, Antibody Dependant IgG or IgM antibodies react with cell antigens with resultant complement activation Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease
III: Immune Complex IgG immune complex deposition and subsequent complement activation Serum sickness, RA, SLE, post-strep glomerularnephritis
IV: Cell-mediated, Delayed Activated T cells against cell surface antigens TB skin test, chronic transplant rejection, contact dermatitis

See Also

References