Difference between revisions of "Hypersensitivity reaction"

(Text replacement - "Category:Rheum" to "Category:Rheumatology")
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| II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || [[Myasthenia gravis]], [[goodpasture syndrome]], erythroblastalis fetalis, AI hemolytic anemia, Graves disease
 
| II: Cytotoxic, Antibody Dependant || IgG or IgM antibodies react with cell antigens with resultant complement activation || [[Myasthenia gravis]], [[goodpasture syndrome]], erythroblastalis fetalis, AI hemolytic anemia, Graves disease
 
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| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[post-strep glomerularnephritis]]
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| III: Immune Complex || IgG immune complex deposition and subsequent complement activation || [[Serum sickness]], RA, [[SLE]], [[poststreptococcal glomerulonephritis]]
 
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|-
 
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, [[contact dermatitis]]
 
| IV: Cell-mediated, Delayed || Activated T cells against cell surface antigens || TB skin test, chronic transplant rejection, [[contact dermatitis]]

Revision as of 22:48, 27 September 2019

Background

  • Uncomfortable, damaging, and sometimes fatal reactions produced by the normal immune system including allergies and autoimmunity.

Clinical Features

Type Mechanism Example
I: Allergy, Immediate IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization Urticaria, anaphylaxis, angioedema
II: Cytotoxic, Antibody Dependant IgG or IgM antibodies react with cell antigens with resultant complement activation Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease
III: Immune Complex IgG immune complex deposition and subsequent complement activation Serum sickness, RA, SLE, poststreptococcal glomerulonephritis
IV: Cell-mediated, Delayed Activated T cells against cell surface antigens TB skin test, chronic transplant rejection, contact dermatitis

See Also

References