View source for Hydroxyurea

==Administration==
*Type: Antineoplastic
*Dosage Forms:
*Routes of Administration: oral
*Common Trade Names: 

==Adult Dosing==
*Cytoreduction in [[leukostasis and hyperleukocytosis]]/[[hyperviscosity syndrome]]
**50 to 100 mg/kg/day
*Sickle cell disease
**15-35 mg/kg/day
*[[CML]], squamous cell head and neck cancer
**15mg/kg/day initially

==Pediatric Dosing==
*Off label for sickle cell, 10-35mg/kg/day

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*D

===Lactation risk===
*Infant risk cannot be ruledout

===Renal Dosing===
*Reduce dose if CrCl <60. Administer after dialysis on HD days

===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Skin ulceration, skin cancer, gangrene
*Genetic mutations w/longterm use
*Parvovirus infection

===Common===
*Myelosupression, [[neutropenia]], [[thrombocytopenia]], decreased reticulocyte count

==Pharmacology==
*Half-life: 2-4.5 hours
*Metabolism: Hepatic 60%
*Excretion: Renal(40%)

==Mechanism of Action==
*Inhibits DNA synthesis by acting as a ribonucleotide reductase inhibitor

==Comments==


==See Also==


==References==
<references/>

[[Category:Pharmacology]]
[[Category:Heme/Onc]]