Hydrocortisone topical: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Topical steroid]] | ||
*Dosage Forms: | *Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint | ||
*Common Trade Names: | *Common Trade Names: Cortizone, Cortaid, Hytone, Texacort | ||
==Adult Dosing== | ==Adult Dosing== | ||
===Dermatoses, steroid-responsive=== | |||
*Apply bid-QID | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Dermatoses, steroid-responsive=== | |||
*Apply bid-QID | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: Excretion in milk unknown; use with caution | ||
*Renal Dosing | *Renal Dosing: None | ||
*Hepatic Dosing: None | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*caution if skin infection | |||
*caution in pediatric patients | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*HPA axis suppresion | |||
*Cushing syndrome | |||
*hyperglycemia | |||
*intracranial hypertension (pediatric patients) | |||
===Common=== | ===Common=== | ||
*burning | |||
*pruritus | |||
*irritation | |||
*dryness | |||
*folliculitis | |||
*hypertrichosis | |||
*acneiform dermatitis | |||
*hypopigmentation | |||
*perioral dermatitis | |||
*allergic contact dermatitis | |||
*maceration | |||
*secondary infection | |||
*skin atrophy | |||
*striae | |||
*miliaria | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 8-12h | ||
*Metabolism: | *Metabolism: liver primarily; CYP450 | ||
*Excretion: | *Excretion: urine | ||
*Mechanism of Action: | *Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects | ||
==See Also== | ==See Also== | ||
*[[Stress dose steroids]] | |||
*[[Hydrocortisone (systemic)]] | |||
== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category: | [[Category:Dermatology]] | ||
Latest revision as of 16:57, 24 May 2022
General
- Type: Topical steroid
- Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
- Common Trade Names: Cortizone, Cortaid, Hytone, Texacort
Adult Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Pediatric Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Special Populations
- Pregnancy Rating: C
- Lactation: Excretion in milk unknown; use with caution
- Renal Dosing: None
- Hepatic Dosing: None
Contraindications
- Allergy to class/drug
- caution if skin infection
- caution in pediatric patients
Adverse Reactions
Serious
- HPA axis suppresion
- Cushing syndrome
- hyperglycemia
- intracranial hypertension (pediatric patients)
Common
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Pharmacology
- Half-life: 8-12h
- Metabolism: liver primarily; CYP450
- Excretion: urine
- Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects