Hydrocortisone/neomycin/polymyxin
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Administration
- Type: topical antibiotic/steroid
- Dosage Forms:
- Routes of Administration: topical
- Common Trade Names: Cortisporin otic
Adult Dosing
- 4 drops in ear q6-8hr
Pediatric Dosing
- 3 drops in ear q6-8hr
Special Populations
Pregnancy Rating
- Category C
Lactation risk
- Unknown whether drug is excreted in milk; use with caution
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Cutaneous viral infection of the external auditory canal (e.g. patients with herpes simplex, vaccinia, and varicella infections)
Adverse Reactions
Serious
- Neomycin sensitization with itching, reddening, edema, and failure to heal
- Systemic absorption of topical corticosteroids--> HPA axis suppression --> adrenal crisis
- Prolonged use of corticosteroids may lead to increase incidence of infection, masking of infection, limited response to vaccines
- Prolonged use of corticosteroids associated with development of Kaposi sarcoma
Common
- Itching
- Redness
- Rash
- Swelling
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
- Hydrocortisone: Suppresses inflammatory response
- Polymyxin: disrupts bacterial cytoplasmic membrane permeability allowing leakage of intracellular contents--> bactericidal
- Neomycin: Inhibits protein synthesis