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Background
- Abbreviation: HPV
- Most common STI in US.
- Over 200 HPV types, with 40 that infect the genital mucosa [1]
- Associated with cervical, vulvar, penile, anal and oropharyngeal cancer.
- Vaccine available for adolescents 11 and older, and immunocompromised patients.
HPV Types and Associated Disease Entities
Disease
|
HPV type
|
Common warts
|
2, 7, 22
|
Plantar warts
|
1, 2, 4, 63
|
Verruca plana (flat)
|
3, 10, 28
|
Condyloma acuminata (anogenital)
|
6, 11, 42, 44 and others
|
Anal dysplasia (lesions)
|
6, 16, 18, 31, 53, 58
|
Genital cancers
|
- Highest risk: 16, 18, 31, 45
- Other high-risk: 33, 35, 39, 51, 52, 56, 58, 59
- Probably high-risk: 26, 53, 66, 68, 73, 82
|
Epidermodysplasia verruciformis
|
more than 15 types
|
Focal epithelial hyperplasia (mouth)
|
13, 32
|
Mouth papillomas
|
6, 7, 11, 16, 32
|
Oropharyngeal cancer
|
16
|
Verrucous cyst
|
60
|
Laryngeal papillomatosis
|
6, 11
|
Clinical Features
Plantar wart on sole of foot.
- Most infections asymptomatic
- Anogenital warts (Condyloma acuminata)
- painless flesh-colored papules or cauliflower-like projections
- Contagious via skin contact
- Cervical cancer
Differential Diagnosis
Evaluation
- Clinical diagnosis
- Pap smear for cervical lesions
Management
- Safe-sex counseling (HPV-2)
- For genital warts can use:
- Podofilox
- Imiquimod
- Cryotherapy
- Trichloroacetic acid
- Surgical removal
Disposition
See Also
External Links
References