Human papillomavirus: Difference between revisions

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==Background==
==Background==
*Most common STI in US.
*Abbreviation: HPV
*Associated with cervical, vulvar, penile, anal cancer, oropharyngeal cancer.
*Most common [[STI]] in US.
*Vaccine available for adolescents 11 and older, and immunocompromised patients
*Over 200 HPV types, with 40 that infect the genital mucosa <ref> Cdc.gov. (2018). Surveillance Manual | HPV | Vaccine Preventable Diseases | CDC. [online] Available at: https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html [Accessed 3 May 2018]. </ref>
*Associated with cervical, vulvar, penile, anal and oropharyngeal cancer.
*Vaccine available for adolescents 11 and older, and immunocompromised patients.
 
===HPV Types and Associated Disease Entities===
{| class="wikitable" style="margin:1em;"
|-
! Disease
! HPV type
|-
| Common [[wart]]s
| 2, 7, 22
|-
| [[Plantar wart]]s
| 1, 2, 4, 63
|-
| Verruca plana (flat)
| 3, 10, 28
|-
| [[Condyloma acuminata]] (anogenital)
| 6, 11, 42, 44 and others
|-
| Anal dysplasia (lesions)
| 6, 16, 18, 31, 53, 58
|-
| Genital cancers
|
*Highest risk: 16, 18, 31, 45
*Other high-risk: 33, 35, 39, 51, 52, 56, 58, 59
*Probably high-risk: 26, 53, 66, 68, 73, 82
|-
| Epidermodysplasia verruciformis
| more than 15 types
|-
| Focal epithelial hyperplasia (mouth)
| 13, 32
|-
| Mouth papillomas
| 6, 7, 11, 16, 32
|-
| Oropharyngeal cancer
| 16
|-
| Verrucous cyst
| 60
|-
| Laryngeal papillomatosis
| 6, 11
|}


==Clinical Features==
==Clinical Features==
[[File:Dornwarzen.jpg|thumb|Warts on toe.]]
[[File:Largeplanterwart.jpg|thumb|Plantar wart on sole of foot.]]
*Most infections asymptomatic
*Most infections asymptomatic
*Anogenital warts (Condyloma acuminata)
*Anogenital warts ([[Condyloma acuminata]])
**painless flesh-colored papules or cauliflower-like projections
**painless flesh-colored papules or cauliflower-like projections
**Contagious via skin contact
**Contagious via skin contact
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==Differential Diagnosis==
==Differential Diagnosis==
{{STD DDX}}


==Diagnosis==
==Evaluation==
*Clinical dx
*Clinical diagnosis
*Pap smear for cervical lesions
*Pap smear for cervical lesions


==Management==
==Management==
*Safe-sex counseling
*Safe-sex counseling (HPV-2)


==Disposition==
==Disposition==
Outpatient f/u
*Outpatient follow up


==See Also==
==See Also==
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==External Links==
==External Links==
*http://www.cdc.gov/std/hpv/stdfact-hpv.htm


==References==
==References==
1. [http://www.cdc.gov/std/hpv/stdfact-hpv.htm CDC: HPV]
<references/>
<references/>
[[Category:ID]]
[[Category:Dermatology]]
[[Category:OBGYN]]
[[Category:Urology]]

Revision as of 19:38, 10 September 2020

Background

  • Abbreviation: HPV
  • Most common STI in US.
  • Over 200 HPV types, with 40 that infect the genital mucosa [1]
  • Associated with cervical, vulvar, penile, anal and oropharyngeal cancer.
  • Vaccine available for adolescents 11 and older, and immunocompromised patients.

HPV Types and Associated Disease Entities

Disease HPV type
Common warts 2, 7, 22
Plantar warts 1, 2, 4, 63
Verruca plana (flat) 3, 10, 28
Condyloma acuminata (anogenital) 6, 11, 42, 44 and others
Anal dysplasia (lesions) 6, 16, 18, 31, 53, 58
Genital cancers
  • Highest risk: 16, 18, 31, 45
  • Other high-risk: 33, 35, 39, 51, 52, 56, 58, 59
  • Probably high-risk: 26, 53, 66, 68, 73, 82
Epidermodysplasia verruciformis more than 15 types
Focal epithelial hyperplasia (mouth) 13, 32
Mouth papillomas 6, 7, 11, 16, 32
Oropharyngeal cancer 16
Verrucous cyst 60
Laryngeal papillomatosis 6, 11

Clinical Features

Warts on toe.
Plantar wart on sole of foot.
  • Most infections asymptomatic
  • Anogenital warts (Condyloma acuminata)
    • painless flesh-colored papules or cauliflower-like projections
    • Contagious via skin contact
  • Cervical cancer

Differential Diagnosis

Sexually transmitted diseases

Evaluation

  • Clinical diagnosis
  • Pap smear for cervical lesions

Management

  • Safe-sex counseling (HPV-2)

Disposition

  • Outpatient follow up

See Also

External Links

References

  1. Cdc.gov. (2018). Surveillance Manual | HPV | Vaccine Preventable Diseases | CDC. [online] Available at: https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html [Accessed 3 May 2018].