Difference between revisions of "Glyburide"

(Pediatric Dosing)
(References)
 
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[[Category:Pharmacology]]
 
[[Category:Pharmacology]]
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[[Category:Endocrinology]]

Latest revision as of 20:16, 22 September 2019

Administration

  • Type: Sulfonylurea
  • Dosage Forms: Tab: 1.25mg, 2.5 mg, 5 mg
  • Routes of Administration: Oral
  • Common Trade Names: DiaBeta, Micronase

Adult Dosing

Diabetes mellitus, Type 2

  • 1.25-20 mg/day PO divided qd-bid
    • Max: 20mg/day

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Renal Dosing

  • Adult:
    • CrCl <50: Avoid Use
  • Pediatric:
    • No current guidelines

Hepatic Dosing

  • Adult:
    • Start at 1.25 mg qd
  • Pediatric:
    • No current guidelines

Contraindications

Adverse Reactions

Serious

Common

  • Nausea, Dyspepsia
  • Blurred vision
  • Weight gain
  • Drowsiness
  • Rash

Pharmacology

  • Half-life: 10h
  • Metabolism: Liver; CYP2C9 substrate
  • Excretion: Bile 50%, Urine 50%

Mechanism of Action

  • Stimulates pancreatic islet beta cell insulin release

Comments

See Also

Diabetes Medications

References