Fidaxomicin
Administration
- Type: Macrolide antibiotic
- Dosage Forms:
- Routes of Administration: PO
- Common Trade Names:
Adult Dosing
- C. diff diarrhea: 200mg PO BID x 10d
Pediatric Dosing
Safety/efficacy not established
Special Populations
Pregnancy Rating
- Category B
Lactation risk
- Infant risk cannot be ruled out
Renal Dosing
- No adjustment
Hepatic Dosing
- Not established
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: ~12h
- Metabolism: Intestinal
- Excretion: Fecal
Mechanism of Action
- Macrolide: inhibits RNA polymerases primarily against clostridia species