Difference between revisions of "Fentanyl"

(fentanyl drug page)
 
(5 intermediate revisions by 4 users not shown)
Line 11: Line 11:
 
0.5-2 mcg/kg IV q1-2 hr
 
0.5-2 mcg/kg IV q1-2 hr
  
==Special Populations==
+
==Special Populations<ref>Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>==
 
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
 
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
 
*Lactation: Excreted in breast milk, not recommended
 
*Lactation: Excreted in breast milk, not recommended
 
*Renal Dosing
 
*Renal Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined but recommendations for IV:
 +
**** GFR > 50 mL/minute/1.73 m²: no adjustment
 +
**** GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
 +
**** GFR < 10 mL/minute/1.73 m²: 50% of usual dose
 +
**** Hemodialysis: 50% of usual dose
 
*Hepatic Dosing
 
*Hepatic Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined
  
 
==Contraindications==
 
==Contraindications==
Line 41: Line 49:
  
 
==See Also==
 
==See Also==
 +
*[[Intranasal sedation]]
  
==Sources==
+
==References==
Micromedex
 
 
<references/>
 
<references/>
[[Category:Drugs]]
+
[[Category:Pharmacology]]

Latest revision as of 04:45, 2 May 2019

General

  • Type: Opiods
  • Dosage Forms: IV, intranasal, transdermal
  • Common Trade Names: Sublimaze

Adult Dosing

  • Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
  • Sedation: 1-3 mcg/kg/hr continuous infusion

Pediatric Dosing

0.5-2 mcg/kg IV q1-2 hr

Special Populations[1]

  • Pregnancy Rating: C
  • Lactation: Excreted in breast milk, not recommended
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined but recommendations for IV:
        • GFR > 50 mL/minute/1.73 m²: no adjustment
        • GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
        • GFR < 10 mL/minute/1.73 m²: 50% of usual dose
        • Hemodialysis: 50% of usual dose
  • Hepatic Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Apnea

Common

  • Confusion
  • Constipation
  • Nausea/Vomiting
  • Somnolence
  • Sweating
  • Asthenia

Pharmacology

  • Half-life: 2-4 hours
  • Metabolism: Hepatic
  • Excretion: Renal
  • Mechanism of Action: Narcotic opiate receptor agonist

See Also

References

  1. Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.