Difference between revisions of "Fentanyl"

(Created page with "==General== *Type: Opiods *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== *Drug Ratings in Pregnancy|Pregnancy Rati...")
 
 
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==General==
 
==General==
 
*Type: [[Opiods]]
 
*Type: [[Opiods]]
*Dosage Forms:
+
*Dosage Forms: IV, intranasal, transdermal
*Common Trade Names:  
+
*Common Trade Names: Sublimaze
  
 
==Adult Dosing==
 
==Adult Dosing==
 +
*Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
 +
*Sedation: 1-3 mcg/kg/hr continuous infusion
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 +
0.5-2 mcg/kg IV q1-2 hr
  
==Special Populations==
+
==Special Populations<ref>Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*Lactation:
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*Lactation: Excreted in breast milk, not recommended
 
*Renal Dosing
 
*Renal Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined but recommendations for IV:
 +
**** GFR > 50 mL/minute/1.73 m²: no adjustment
 +
**** GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
 +
**** GFR < 10 mL/minute/1.73 m²: 50% of usual dose
 +
**** Hemodialysis: 50% of usual dose
 
*Hepatic Dosing
 
*Hepatic Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined
  
 
==Contraindications==
 
==Contraindications==
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==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
 
+
*Apnea
 
===Common===
 
===Common===
 
+
*Confusion
 +
*Constipation
 +
*Nausea/Vomiting
 +
*Somnolence
 +
*Sweating
 +
*Asthenia
 
==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 2-4 hours
*Metabolism:  
+
*Metabolism: Hepatic
*Excretion:  
+
*Excretion: Renal
*Mechanism of Action:
+
*Mechanism of Action: Narcotic opiate receptor agonist
  
 
==See Also==
 
==See Also==
 +
*[[Intranasal sedation]]
  
==Sources==
+
==References==
 
 
 
<references/>
 
<references/>
[[Category:Drugs]]
+
[[Category:Pharmacology]]

Latest revision as of 04:45, 2 May 2019

General

  • Type: Opiods
  • Dosage Forms: IV, intranasal, transdermal
  • Common Trade Names: Sublimaze

Adult Dosing

  • Analgesia: 1-2 mcg/kg IV/IM, q30-60 min PRN
  • Sedation: 1-3 mcg/kg/hr continuous infusion

Pediatric Dosing

0.5-2 mcg/kg IV q1-2 hr

Special Populations[1]

  • Pregnancy Rating: C
  • Lactation: Excreted in breast milk, not recommended
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined but recommendations for IV:
        • GFR > 50 mL/minute/1.73 m²: no adjustment
        • GFR 10 to 50 mL/minute/1.73 m²: 75% of usual dose
        • GFR < 10 mL/minute/1.73 m²: 50% of usual dose
        • Hemodialysis: 50% of usual dose
  • Hepatic Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Apnea

Common

  • Confusion
  • Constipation
  • Nausea/Vomiting
  • Somnolence
  • Sweating
  • Asthenia

Pharmacology

  • Half-life: 2-4 hours
  • Metabolism: Hepatic
  • Excretion: Renal
  • Mechanism of Action: Narcotic opiate receptor agonist

See Also

References

  1. Fentanyl: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.