Etomidate
See critical care quick reference for drug doses by weight.
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
RSI
- 0.3mg/kg bolus IV
- Standard dose = 20mg
Procedural Sedation
- 0.1mg/kg one time dosing
- Max: 10mg
- Minimal respiratory depression but decrease blood pressure and heart rate (alpha2 agonism)
Pediatric Dosing
See critical care quick reference for drug doses by weight.
RSI
- 0.3mg/kg bolus IV
- Max: 20mg
Procedural Sedation
- 0.1mg/kg one time dosing
- Max: 10mg
- Minimal respiratory depression but decrease blood pressure and heart rate (alpha2 agonism)
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Myoclonus
- Nausea/Vomiting
- Pain at injection site
- apnea
Controversy
"The available evidence suggests that etomidate suppresses adrenal function transiently without demonstrating a significant effect on mortality. However, no studies to date have been powered to detect a difference in hospital, ventilator, or ICU length of stay or in mortality."[1]
Pharmacology
- Half-life: 75 minutes
- Metabolism: Liver
- Excretion: Urine
- Mechanism of Action: GABA agonist
See Also
References
- ↑ *Hohl CM, Kelly-Smith CH,Yeung TC, Sweet DD, Doyle-Waters MM, Schulzer M. The effect of a bolus dose of Etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med. 2010;56(2):105-113.