Erythema infectiosum

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Background

Clinical Features

  • Initially mild URI-type symptoms
    • Malaise, myalgias, and headache 7-10 days prior to rash [1]
  • "Slapped cheeks" rash
    • Abrupt appearance on day 3-4
      • Spares eyelids and chin
    • Lasts 4-5 days
  • Macular erythema develops on trunk/limbs 2 days after appearance of facial rash
    • Distinctive aspect of rash: faces with central clearing, giving a reticulated or lacy appearance
    • May last 1 week
    • Rash may recur within 3 week period
  • Papulopurpuric glove-and-sock syndrome
  • Associated symptoms include fever, headache, sore throat, cough, coryza, nausea and vomiting
Fifths Disease

Differential Diagnosis

Pediatric Rash

Evaluation

  • Clinical diagnosis, based on history and physical exam

Management

  • Symptomatic

Disposition

  • Discharge most patients
    • Referral to maternal-fetal medicine specialist for infection in pregnancy
  • Admit if aplastic crisis

Complications

See Also

References

  1. Sara Bode; Contagious Exanthematous Diseases. Quick References 2022; 10.1542/aap.ppcqr.396150
  2. Shirk A, Sorrentino A. Viral Exanthems. In: Schafermeyer R, Tenenbein M, Macias CG, Sharieff GQ, Yamamoto LG. eds. Strange and Schafermeyer's Pediatric Emergency Medicine, 4e. New York, NY: McGraw-Hill; 2015