Epinephrine: Difference between revisions
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*Type: [[Vasopressors]] | *Type: [[Vasopressors]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Common Trade Names: | *Concentration | ||
**Amount of solution in mL used to dilute 1,000mg of epinephrine | |||
**eg 1:10,000 = 1,000mg/10,000mL = 0.1mg/mL | |||
*Common Trade Names: Adrenaline | |||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Anaphylaxis]]=== | |||
0.3-0.5mg of 1:1,000 IM | |||
*Consider glucagon 1-5mg IV if pt on B-blockers and not responding to epi | |||
===[[Anaphylactic shock]]=== | |||
0.1mg of 1:10,000 slow IV during 5 min, can start infusion of 1-4 mcg/min | |||
===[[Cardiac Arrest]]=== | |||
1mg of 1:10,000 IVP | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''See [[critical care quick reference]] for drug doses by weight.'' | |||
==Special Populations== | ==Special Populations== | ||
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*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | |||
*β1 | |||
*α1 | |||
*β2 | |||
===Relative Effects=== | |||
*↑↑↑HR | |||
*↑↑↑SV | |||
*↑↑↑SVR | |||
*Bronchodilation (β2) | |||
==See Also== | ==See Also== | ||
*[[Digital EpiPen Injection]] | |||
*[[Critical care quick reference]] | |||
==Sources== | ==Sources== | ||
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<references/> | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
==Pressor== | ==Pressor== | ||
===Dosing=== | ===Dosing=== | ||
*Dose-dependent effects: | *Dose-dependent effects: | ||
Revision as of 14:37, 20 December 2014
General
- Type: Vasopressors
- Dosage Forms:
- Concentration
- Amount of solution in mL used to dilute 1,000mg of epinephrine
- eg 1:10,000 = 1,000mg/10,000mL = 0.1mg/mL
- Common Trade Names: Adrenaline
Adult Dosing
Anaphylaxis
0.3-0.5mg of 1:1,000 IM
- Consider glucagon 1-5mg IV if pt on B-blockers and not responding to epi
Anaphylactic shock
0.1mg of 1:10,000 slow IV during 5 min, can start infusion of 1-4 mcg/min
Cardiac Arrest
1mg of 1:10,000 IVP
Pediatric Dosing
See critical care quick reference for drug doses by weight.
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- β1
- α1
- β2
Relative Effects
- ↑↑↑HR
- ↑↑↑SV
- ↑↑↑SVR
- Bronchodilation (β2)
See Also
Sources
Pressor
Dosing
- Dose-dependent effects:
- 1-10 mcg/min - increase HR and SV
- 10-20 mcg/min - increase SVR
Rate of Titration
- Q2-5 min
Adverse Effects
- Tachyarrhythmias
- Myocardial ischemia
- ↑Serum lactate
- Splanchnic ischemia
Notes
- ↑lactate occurs primarily from ↑glycolysis/glycogenolysis within skeletal muscles not tissue hypoperfusion
- Use with caution in pts with CAD
- However clinical trials have not demonstrated worsened outcomes