Enoxaparin: Difference between revisions
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Revision as of 15:52, 22 March 2016
General
- Type: Low molecular weight heparin
- Dosage Forms:
- Common Trade Names: Lovenox
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Renal impairment (Cr clearance <30)
- Use 50% of usual dose or use UFH instead
- Adult
- Pediatric
- Renal impairment (Cr clearance <30)
- Hepatic Dosing
- Adult
- Pediatric
- Obesity
- Weight-based dosing safe up to 190kg (no data available thereafter)
Indications
Contraindications
- Allergy to class/drug
Adverse Reactions
- Bleeding
- Less common than with UFH
- Treatment
- Protamine
- Does not completely reverse LMWHs
- Carries significant anaphylaxis risk (0.2%); only use for major bleeding
- Dosing
- For Enoxaparin: protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
- If 8–12h since last enoxaparin dose give 0.5mg IV for every 1mg of enoxaparin given
- For Enoxaparin: protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
- Protamine
- Pruritus
- Local skin reaction
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: