Edrophonium

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Administration

  • Type: Cholinesterase inhibitor
  • Dosage Forms: INJ
  • Routes of Administration: IV, IM
  • Common Trade Names: Enlon, Tensilon

Adult Dosing

  • Myasthenic crisis, diagnosis
    • 1 mg IV x2 doses
      • Max: 2 mg cumulative dose
      • Give second dose 1 min later if no impairment due to 1st dose
  • Nondepolarizing neuromuscular blockade reversal
    • 10 mg IV x1 dose
      • Repeat dose PRN. Max: 40mg
  • Myasthenia gravis, diagnosis
    • 2 mg IV x1dose
      • If no cholinergic rxn after 45s, give 8 mg IV x1 dose
      • Give atropine sulfate 0.4-0.5 mg IV x1 dose if rxn from 2 mg edrophonium dose
    • 10 mg IM x1 dose
      • If cholinergic rxn, give 2 mg IM x1 dose 30 min after 1st dose
  • Myasthenia gravis, tx evaluation
    • 1-2 mg IV x1 dose
      • 1h after PO tx drug

Pediatric Dosing

  • Myasthenia gravis, diagnosis
    • Infants
      • 0.5 mg IV x1 dose
    • <75 lb
      • 1 mg IV x1 dose
        • Max: 5 mg cumulative dose
        • Alt: 5 mg IM x1 dose
    • >75 lb
      • 2 mg IV x1 dose
        • Max: 10 mg cumulative dose
        • Alt: 5 mg IM x1 dose

Special Populations

  • Pregnancy Rating: C; Caution advised in pregnancy, esp. in 3rd trimester
  • Lactation risk: Probably safe; Limited information demonstrates no risk. Caution advised.

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • GI obstruction
  • Urinary obstruction
  • Caution if hypersensitivity to sulfites
  • Caution if asthma
  • Caution if arrhythmias

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 33-110 min
  • Metabolism: Unknown
  • Excretion: Urine

Mechanism of Action

Reversibly binds to and inactivates acetylcholinesterases.

Comments

See Also

References