EBQ:ARDSnet Trial
incomplete Journal Club Article
Brower RG, et al. "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome". The New England Journal of Medicine. 2000. 342(18):1301-1308.
PubMed Full text PDF
PubMed Full text PDF
Clinical Question
Does a lung protective strategy of low tidal volumes in patients with Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) decrease mortality and ventilator-free days when compared to traditional ventilation strategies.
Conclusion
In patients with ALI/ARDS, lower tidal volumes of 6mL/kg ideal body weight reduces mortality and decreases length of time on mechanical ventilation.
Major Points
- Acute Respiratory Distress Syndrome results from alveolar damage and barotrauma are associated with elevated plateau pressures and higher tidal volume ventilations
- The trial was stopped early when patients in the low tidal volumes arm showed a significant decrease in mortality and more ventilator-free days compared to the traditional tidal volumes arm.
Guidelines
Design
Multicenter, randomized trial of 861 patients
Population
Inclusion Criteria
Exclusion Criteria
Baseline Characteristics
Interventions
Outcomes
Primary Outcomes
Secondary Outcomes
Criticisms
Funding
The National Heart, Lung, and Blood Institute.
CME