Dopamine: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Class C | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Class C | ||
*Lactation: | *Lactation: Use caution (limited data) | ||
*Renal Dosing | *Renal Dosing | ||
**Adult: no adjustment | **Adult: no adjustment | ||
Line 37: | Line 37: | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Tachyarrhythmias | *Tachyarrhythmias | ||
*Pheochromocytoma | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | |||
*[[Hypotension]] | |||
*Ventricular arrhythmias | |||
*Bronchospasm | |||
*[[Atrial fibrillation]] | |||
*Extravasation necrosis | |||
*Gangrene | |||
===Common=== | ===Common=== | ||
*[[Tachycardia]] | |||
*[[Headache]] | |||
*Nausea/vomiting | |||
*Anxiety | |||
*[[Hypertension]] | |||
*[[Angina]] | |||
*[[Palpitations]] | |||
*[[Dyspnea]] | |||
*Azotemia | |||
==Pharmacology<ref>Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ==Pharmacology<ref>Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
Line 74: | Line 84: | ||
==See Also== | ==See Also== | ||
*[[Vasopressors]] | |||
*[[Dobutamine]] | |||
*[[Cardiogenic shock]] | |||
*[[Shock]] | |||
==References== | ==References== |
Revision as of 18:57, 16 March 2020
General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Adult Dosing
Dosing
- Shock (adjunct):
- 1-50 mcg/kg/min IV
- Max 20-50 mcg/kg/min
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- 1-50 mcg/kg/min IV
- Refractory Heart Failure:
- 1-3 mcg/kg/min IV
- Bradycardia (in patients unresponsive to atropine):
- 2-10 mcg/kg/min IV
- Post-resuscitation stabilization:
- 5-10 mcg/kg/min IV
Pediatric Dosing
- Shock (adjunct):
- 5-20 mcg/kg/min IV
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- 5-20 mcg/kg/min IV
- Post-resuscitation stabilization:
- 2-20 mcg/kg/min IV/IO
Special Populations
- Pregnancy Rating: Class C
- Lactation: Use caution (limited data)
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: N/A
- Pediatric: N/A
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
- Pheochromocytoma
Adverse Reactions
Serious
- Anaphylaxis
- Hypotension
- Ventricular arrhythmias
- Bronchospasm
- Atrial fibrillation
- Extravasation necrosis
- Gangrene
Common
- Tachycardia
- Headache
- Nausea/vomiting
- Anxiety
- Hypertension
- Angina
- Palpitations
- Dyspnea
- Azotemia
Pharmacology[1]
- Half-life:
- 2 minutes
- Metabolism:
- Renal, Hepatic, Plasma
- Excretion:
- Urine as metabolites
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
Notes
Indications
- Hypotension caused by:
- Septic shock
- MI
- Trauma/spinal shock
- Heart failure
See Also
References
- ↑ Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.