Dobutamine: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: | ||
** 2 minutes | |||
*Metabolism: | *Metabolism: | ||
** In tissues and hepatically | |||
*Excretion: | *Excretion: | ||
** Urine as metabolites | |||
*Mechanism of Action:β<sub>1</sub> stimulation with variable BP effects | *Mechanism of Action:β<sub>1</sub> stimulation with variable BP effects | ||
===Primary Receptor=== | ===Primary Receptor=== | ||
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*↑↑↑SV | *↑↑↑SV | ||
*↑↑HR → increases oxygen demand of heart → can worsen ischemia | *↑↑HR → increases oxygen demand of heart → can worsen ischemia | ||
*↓SVR (transient, from β<sub>2</sub> agonism) | *↓SVR (transient, from β<sub>2</sub> agonism) | ||
==Notes== | ==Notes== |
Revision as of 19:05, 2 April 2019
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- 2-20mcg/kg/min
- 10mcg works for most
- May use in peripheral IV
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Unknown if Dobutamine passes into breast milk
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
- Tachyarrhythmias
- Myocardial ischemia
- Hypotension as β2 effect may result in vasodilation
- Caution if SBP <90
Serious
Common
Pharmacology
- Half-life:
- 2 minutes
- Metabolism:
- In tissues and hepatically
- Excretion:
- Urine as metabolites
- Mechanism of Action:β1 stimulation with variable BP effects
Primary Receptor
- β1
- β2
Relative Effects
- ↑↑↑SV
- ↑↑HR → increases oxygen demand of heart → can worsen ischemia
- ↓SVR (transient, from β2 agonism)
Notes
Indications
- Cardiogenic shock
- initial agent in low-output heart failure without requiring BP support
- Tricyclic overdose
- septic shock with low cardiac output to improve blood flow