Dobutamine: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "β2" to "β<sub>2</sub>") |
Neil.m.young (talk | contribs) (Text replacement - "β1" to "β<sub>1</sub>") |
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*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action:β<sub>1</sub> stimulation with variable BP effects | ||
===Primary Receptor=== | ===Primary Receptor=== | ||
* | *β<sub>1</sub> | ||
*β<sub>2</sub> | *β<sub>2</sub> | ||
===Relative Effects=== | ===Relative Effects=== | ||
Revision as of 11:19, 5 August 2017
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- 2-20mcg/kg/min
- 10mcg works for most
- May use in peripheral IV
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Tachyarrhythmias
- Myocardial ischemia
- Hypotensionas β2 effect may result in vasodilation
- Caution if SBP <90
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:β1 stimulation with variable BP effects
Primary Receptor
- β1
- β2
Relative Effects
- ↑↑↑SV
- ↑↑HR --> increases oxygen demand of heart --> can worsen ischemia
- ↓SVR (transient, from β2 agonism)
Notes
Indications
- Cardiogenic shock
- initial agent in low-output heart failure without requiring BP support
- Tricyclic overdose
- septic shock with low cardiac output to improve blood flow