Dipyridamole

Administration

• Type: Antiplatelet
• Dosage Forms: Tablet 25mg, 50mg, 75mg; INJ
• Routes of Administration: Oral, IV
• Common Trade Names: Persantine

Adult Dosing

Cardiac Stress Testing

• 0.142 mg/kg/min IV x4min

Thromboembolism prevention adjunct for cardiac valve

• 75-100 mg PO qid

Thromboembolism prevention

• 50=100 mg PO qid

Angina prophylaxis

• 50 mg PO tid

Pediatric Dosing

Thromboembolism prevention adjunct for cardiac valve

• 2-5 mg/kg/day PO divided tid
  • Give with warfarin or aspirin

Special Populations

Pregnancy Rating

• Caution advised during pregnancy
• Risk of increased maternal bleeding during delivery

Lactation risk

• Caution advised while breastfeeding

Renal Dosing

• Adult: No adjustment
• Pediatric: No adjustment

Hepatic Dosing

• Adult: Not defined
• Pediatric: Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Hypotension
• Bronchospasm, IV use
• Myocardial infarction, IV use
• Arrhythmia, IV use

Common

• Angina exacerbation
• Dizziness, Hypotension, Nausea, Headache
• Flushing, Rash
• Vomiting, Diarrhea, Abdominal pain

Pharmacology

• Half-life: 10 hours
• Metabolism: Liver
• Excretion: Bile

Mechanism of Action

• Inhibits platelet adenosine uptake, reducing platelet aggregation
• Augments cGMP production, dilating coronary arteries

See Also

• Antiplatelet medications
• Antiplatelet agent reversal