Dipyridamole

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Administration

  • Type: Antiplatelet
  • Dosage Forms: Tablet 25mg, 50mg, 75mg; INJ
  • Routes of Administration: Oral, IV
  • Common Trade Names: Persantine

Adult Dosing

Cardiac Stress Testing

  • 0.142 mg/kg/min IV x4min

Thromboembolism prevention adjunct for cardiac valve

  • 75-100 mg PO qid

Thromboembolism prevention

  • 50=100 mg PO qid

Angina prophylaxis

  • 50 mg PO tid

Pediatric Dosing

Thromboembolism prevention adjunct for cardiac valve

Special Populations

Pregnancy Rating

  • Caution advised during pregnancy
  • Risk of increased maternal bleeding during delivery

Lactation risk

  • Caution advised while breastfeeding

Renal Dosing

  • Adult: No adjustment
  • Pediatric: No adjustment

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 10 hours
  • Metabolism: Liver
  • Excretion: Bile

Mechanism of Action

  • Inhibits platelet adenosine uptake, reducing platelet aggregation
  • Augments cGMP production, dilating coronary arteries

Comments

See Also

References

Authors:

Jonathan Warren