Diltiazem: Difference between revisions
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== Adult Dosing == | ==Adult Dosing== | ||
*Loading dose = 0.25mg/kg (max=20mg) IV bolus over 2min | *Loading dose = 0.25mg/kg (max=20mg) IV bolus over 2min | ||
**If ineffective after 15min: 0.35mg/ | **If ineffective after 15min: 0.35mg/kg (max=25mg) over 2min | ||
**If effective: Start infusion at 5-15mg/hr | **If effective: Start infusion at 5-15mg/hr | ||
== Contraindications == | ==Pediatric Dosing== | ||
*See [[critical care quick reference]] for drug doses by weight | |||
==Special Populations== | |||
* Pregnancy Rating: | |||
* Lactation: | |||
* Renal Dosing | |||
** Adult | |||
** Pediatric | |||
* Hepatic Dosing | |||
** Adult | |||
** Pediatric | |||
==Contraindications== | |||
*Wide-complex tachycardia due to bypass tract | *Wide-complex tachycardia due to bypass tract | ||
== Indications == | ==Indications== | ||
*Conversion of PSVT to NSR | *Conversion of PSVT to NSR | ||
*Slow RVR in a-fib/flutter | *Slow RVR in a-fib/flutter | ||
== Mechanism of Action == | ==Mechanism of Action== | ||
*Class IV - Inhibits Ca influx | *Class IV - Inhibits Ca influx | ||
**Slows AV nodal conduction | **Slows AV nodal conduction | ||
== Adverse Drug | ==Adverse Drug Reactionss== | ||
Bradycardia, CHF, AV block, BBB, hypotension | Bradycardia, CHF, AV block, BBB, hypotension | ||
== Kinetics == | ==Kinetics== | ||
*Onset of action = 2-3min (IV) | *Onset of action = 2-3min (IV) | ||
*Duration of action = 1-3hr (IV) | *Duration of action = 1-3hr (IV) | ||
==See Also== | ==See Also== | ||
[[Antiarrhythmics]] | *[[Antiarrhythmics]] | ||
*[[Calcium Channel Blocker Toxicity]] | |||
*[[Atrial Fibrillation with RVR]] | |||
[[Category: | [[Category:Pharmacology]] | ||
Revision as of 18:45, 2 April 2019
Adult Dosing
- Loading dose = 0.25mg/kg (max=20mg) IV bolus over 2min
- If ineffective after 15min: 0.35mg/kg (max=25mg) over 2min
- If effective: Start infusion at 5-15mg/hr
Pediatric Dosing
- See critical care quick reference for drug doses by weight
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Wide-complex tachycardia due to bypass tract
Indications
- Conversion of PSVT to NSR
- Slow RVR in a-fib/flutter
Mechanism of Action
- Class IV - Inhibits Ca influx
- Slows AV nodal conduction
Adverse Drug Reactionss
Bradycardia, CHF, AV block, BBB, hypotension
Kinetics
- Onset of action = 2-3min (IV)
- Duration of action = 1-3hr (IV)