Diazepam: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
* Anxiety | |||
** PO: 2 - 10 mg 2-4 times daily | |||
* Muscle spasm | |||
** PO: 2 - 10 mg 2-4 times daily | |||
* Sedation in ICU | |||
** IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D | ||
*Lactation: | *Lactation: Diazepam and metabolites are present in breast milk | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
*** Not defined | |||
**Pediatric | **Pediatric | ||
*** Not defined | |||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult | ||
*** Not defined, use with caution, do not used oral tablets in severe hepatic impairment | |||
**Pediatric | **Pediatric | ||
*** Not defined, use with caution, do not used oral tablets in severe hepatic impairment | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* severe hepatic impairment | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* Respiratory/CNS depression | |||
* Hypotension | |||
* paradoxical CNS stimulation | |||
===Common=== | ===Common=== | ||
* drowsiness | |||
* disinhibition | |||
* ataxia | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 30-60 hours | ||
*Metabolism: | *Metabolism: Liver | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: GABA agonist | ||
==See Also== | ==See Also== | ||
==References== | |||
<references/> | <references/> | ||
* Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. | |||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Neurology]] | |||
Latest revision as of 23:54, 20 September 2019
General
- Type: Benzodiazepines
- Dosage Forms:
- Common Trade Names: Valium
Adult Dosing
- Anxiety
- PO: 2 - 10 mg 2-4 times daily
- Muscle spasm
- PO: 2 - 10 mg 2-4 times daily
- Sedation in ICU
- IV: Loading dose: 5 - 10 mg, Maintenance dose: 0.03 - 0.1 mg/kg every 30 minutes to 6 hours
Pediatric Dosing
Special Populations
- Pregnancy Rating: D
- Lactation: Diazepam and metabolites are present in breast milk
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- Not defined, use with caution, do not used oral tablets in severe hepatic impairment
- Pediatric
- Not defined, use with caution, do not used oral tablets in severe hepatic impairment
- Adult
Contraindications
- Allergy to class/drug
- severe hepatic impairment
Adverse Reactions
Serious
- Respiratory/CNS depression
- Hypotension
- paradoxical CNS stimulation
Common
- drowsiness
- disinhibition
- ataxia
Pharmacology
- Half-life: 30-60 hours
- Metabolism: Liver
- Excretion: Urine
- Mechanism of Action: GABA agonist
See Also
References
- Diazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.