Dialyzable drugs: Difference between revisions

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==Background==
==Background==
===Factors Influencing If Dializable===
===Factors Influencing Dialyzability===
*Molecular weight
'''Molecular weight'''
**Smaller molecular weight substances will pass through the dialysis membrane more easily than larger molecular weights.
*Smaller molecular weight substances will pass through the dialysis membrane more easily than larger molecular weights.
*Protein Binding
'''Protein Binding'''
**Drugs with a high degree of protein binding will have a small plasma concentration of unbound drug available for dialysis, making them poorly dialyzable or requiring multiple sessions.
*Drugs with a high degree of protein binding will have a small plasma concentration of unbound drug available for dialysis, making them poorly dialyzable or requiring multiple sessions.
*Volume of Distribution
'''Volume of Distribution'''
**Drugs with large volumes of distribution usually due to lipid solubility and low plasma protein binding are poorly diliazable.
*Drugs with large volumes of distribution usually due to lipid solubility and low plasma protein binding are poorly diliazable.
*Plasma clearance
'''Plasma clearance'''
**Although plasma clearance may be beneficial, increasing plasma clearance will dcrease dialysis clearance.
*Although plasma clearance may be beneficial, increasing plasma clearance will dcrease dialysis clearance.
*Dialysis Flow Rates
'''Dialysis Flow Rates'''
**Greater degrees of dialysis can be achieved with faster dialysate flow rates if the dialysate drug concentrations is low. As the concentration of drug is increased in the diasylate the flow rate needs to be lowered.
*Greater degrees of dialysis can be achieved with faster dialysate flow rates if the dialysate drug concentrations is low. As the concentration of drug is increased in the diasylate the flow rate needs to be lowered.


==Common Dialyzable Drugs==
==Common Dialyzable Drugs==
''Mnemonics BLISTMED and ISTUMBLED:''
*B - [[Barbiturate toxicity|Barbiturates]]
*B - [[Barbiturate toxicity|Barbiturates]]
*L - [[Lithium Toxicity|Lithium]]
*L - [[Lithium Toxicity|Lithium]]
Line 18: Line 21:
*S - [[Aspirin (Salicylate) Toxicity|Salicylates]]
*S - [[Aspirin (Salicylate) Toxicity|Salicylates]]
*T - [[Theophylline toxicity|Theophyline]]/[[Caffeine toxicity|Caffeine]] (both are methylxanthines)
*T - [[Theophylline toxicity|Theophyline]]/[[Caffeine toxicity|Caffeine]] (both are methylxanthines)
*M - [[Methanol Toxicity|Methanol]]
*M - [[Methanol Toxicity|Methanol]], [[metformin]]
*E - [[Ethylene glycol toxicity|Ethylene glycol]]
*E - [[Ethylene glycol toxicity|Ethylene glycol]]
*D - Depakote
*D - [[Depakote]], [[dabigatran]]
*Others - [[Carbamazepine Toxicity|Carbamezepine]]
*Others - [[Carbamazepine Toxicity|Carbamezepine]]


==Complete dializable drug list<ref>Dialysis of Drugs. Nephrology Pharmacy Associates. 2000. </ref>==
 
{| {{table}}
*I - [[INH]]/[[isopropyl alcohol]]
| align="center" style="background:#f0f0f0;"|'''Drug Name'''
*S - [[Salicylates]]
| align="center" style="background:#f0f0f0;"|'''Conventional Dialysis'''
*T - [[Theophylline]]
| align="center" style="background:#f0f0f0;"|'''High Permeability'''
*U - [[Uremia]]
| align="center" style="background:#f0f0f0;"|'''Peritoneal Dialysis'''
*M - [[Methanol]]
|-
*B - [[Barbiturates]]
| Amiloride||ND||ND||ND
*L - [[Lithium]]
|-
*E - [[Ethylene glycol]]
| Aminocaproic acid||Yes||ND||Yes
*D - [[Dabigatran]], [[depakote]]
|-
| Aminoglutethimide||Yes||L||ND
|-
| Aminosalicylic acid||Yes||L||ND
|-
| Amiodarone||No||ND||No
|-
| Amitriptyline||No||ND||No
|-
| Amlodipine||No||ND||No
|-
| Amoxapine||U||ND||U
|-
| Amoxicillin||Yes||L||No
|-
| Amphotericin B||No||ND||No
|-
| Ampicillin||Yes||L||No
|-
| Amprenavir||U||ND||ND
|-
| Amrinone||U||ND||No
|-
| Anagrelide||ND||ND||ND
|-
| Anastrozole||ND||ND||ND
|-
| Anistreplase||U||ND||U
|-
| Antithymocyte globulin ATG||U||ND||U
|-
| Aprotinin||U||ND||U
|-
| Arbutamine||ND||ND||ND
|-
| Ardeparin||No||ND||ND
|-
| Asparaginase||U||ND||U
|-
| Aspirin||Yes||L||Yes
|-
| Atenolol||Yes||L||No
|-
| Atorvastatin||U||ND||U
|-
| Atovaquone||U||ND||U
|-
| Atracurium||U||ND||U
|-
| Atropine||No||ND||ND
|-
| Auranofin||No||ND||ND
|-
| Azathioprine||Yes||L||ND
|-
| Azithromycin||ND||ND||ND
|-
| Azlocillin||Yes||L||No
|-
| Aztreonam||Yes||L||No
|-
| Baclofen||ND||ND||ND
|-
| Basiliximab||U||ND||U
|-
| Benazepril (benazeprilat)||No||ND||ND
|-
| Benzquinamide||U||ND||NA
|-
| Bepridil||No||ND||U
|-
| Betamethasone||ND||ND||ND
|-
| Betaxolol||No||ND||No
|-
| Bethanechol||ND||ND||ND
|-
| Bezafibrate||No||ND||No
|-
| Biapenem||Yes||L||ND
|-
| Bicalutamide||U||ND||U
|-
| Bisoprolol||No||ND||ND
|-
| Bleomycin||No||ND||No
|-
| Bretylium||Yes||L||ND
|-
| Bromfenac||No||ND||U
|-
| Bromocriptine||U||ND||U
|-
| Buflomedil||No||No||U
|-
| Bumetanide||No||ND||U
|-
| Bupropion||No||ND||No
|-
| Buspirone||No||ND||ND
|-
| Busulfan||ND||ND||ND
|-
| Butalbital||ND||ND||ND
|-
| Butorphanol||U||ND||U
|-
| Caffeine||ND||ND||ND
|-
| Calcitriol||No||No||U
|-
| Candesartan||No||ND||ND
|-
| Capecitabine||ND||ND||ND
|-
| Capreomycin||Yes||L||ND
|-
| Captopril||Yes||L||No
|-
| Carbamazepine||No||ND||No
|-
| Carbenicillin||Yes||L||No
|-
| Carbidopa/levodopa||ND||ND||ND
|-
| Carboplatin||Yes||L||ND
|-
| Carboprost||ND||ND||ND
|-
| Carisoprodol||Yes||L||Yes
|-
| Carmustine||No||ND||ND
|-
| Carnitine||Yes||L||ND
|-
| Carprofen||U||ND||U
|-
| Carteolol||ND||ND||ND
|-
| Carumonam||Yes||L||ND
|-
| Carvedilol||No||ND||ND
|-
| Cefaclor||Yes||L||Yes
|-
| Cefadroxil||Yes||L||No
|-
| Cefamandole||Yes||L||No
|-
| Cefazolin||Yes||L||No
|-
| Cefdinir||Yes||L||ND
|-
| Cefepime||Yes||L||Yes
|-
| Cefixime||No||ND||No
|-
| Cefmenoxime||Yes||L||ND
|-
| Cefmetazole||Yes||L||No
|-
| Cefodizime||No||ND||No
|-
| Cefonicid||No||ND||No
|-
| Cefoperazone||No||ND||No
|-
| Ceforanide||Yes||L||No
|-
| Cefotaxime||Yes||L||No
|-
| Cefotetan||Yes||L||Yes
|-
| Cefoxitin||Yes||L||No
|-
| Cefpirome||Yes||Yes||No
|-
| Cefpodoxime||Yes||L||No
|-
| Cefprozil||Yes||L||ND
|-
| Cefroxadine||ND||ND||ND
|-
| Cefsulodin||Yes||L||Yes
|-
| Ceftazidime||Yes||L||Yes
|-
| Ceftibuten||Yes||L||ND
|-
| Ceftizoxime||Yes||L||No
|-
| Ceftriaxone||No||ND||No
|-
| Cefuroxime||Yes||L||No
|-
| Celecoxib||U||ND||U
|-
| Cephalexin||Yes||L||No
|-
| Cephalothin||Yes||L||No
|-
| Cephapirin||Yes||L||No
|-
| Cephradine||Yes||L||Yes
|-
| Cerivastatin||U||ND||U
|-
| Cetirizine||No||ND||U
|-
| Chloral Hydrate||Yes||L||ND
|-
| Chlorambucil||No||ND||No
|-
| Chloramphenicol||Yes||L||No
|-
| Chlordiazepoxide||No||ND||U
|-
| Chloroquine||No||ND||No
|-
| Chlorpheniramine||Yes||L||No
|-
| Chlorpromazine||No||ND||No
|-
| Chlorpropamide||No||ND||No
|-
| Chlorprothixene||U||ND||U
|-
| Chlorthalidone||No||ND||U
|-
| Cidofovir||ND||Yes||No
|-
| Cilastatin||Yes||L||ND
|-
| Cilazapril||Yes||L||ND
|-
| Cilostazol||U||ND||U
|-
| Cimetidine||No||ND||No
|-
| Cinoxacin||No||ND||U
|-
| Ciprofloxacin||No||ND||No
|-
| Cisapride||No||ND||U
|-
| Cisatracurium||U||ND||U
|-
| Cisplatin||No||ND||ND
|-
| Citalopram||U||ND||U
|-
| Cladribine||ND||ND||ND
|-
| Clarithromycin||ND||ND||ND
|-
| Clavulanic acid||Yes||ND||Yes
|-
| Clemastine||ND||ND||ND
|-
| Clindamycin||No||ND||No
|-
| Clodronate||Yes||ND||No
|-
| Clofazimine||No||ND||No
|-
| Clofibrate||No||ND||No
|-
| Clomipramine||U||ND||U
|-
| Clonazepam||No||ND||U
|-
| Clonidine||No||ND||No
|-
| Clopidogrel||U||ND||U
|-
| Clorazepate||No||ND||U
|-
| Cloxacillin||No||ND||No
|-
| Clozapine||U||ND||U
|-
| Codeine||No||ND||U
|-
| Colchicine||No||ND||No
|-
| Cortisone||No||ND||No
|-
| Cyclacillin||Yes||L||No
|-
| Cyclophosphamide||Yes||L||ND
|-
| Cycloserine||Yes||L||ND
|-
| Cyclosporine||No||ND||No
|-
| Cysteamine||ND||ND||No
|-
| Cytarabine||No||ND||No
|-
| Dacarbazine||ND||ND||ND
|-
| Daclizumab||U||ND||U
|-
| Dactinomycin||ND||ND||ND
|-
| Dalteparin||U||ND||U
|-
| Danaparoid||ND||ND||ND
|-
| Dapsone||Yes||L||ND
|-
| Daunorubicin||ND||ND||ND
|-
| Deferoxamine||Yes||L||ND
|-
| Deflazacort||No||ND||U
|-
| Delavirdine||U||ND||U
|-
| Desipramine||No||ND||No
|-
| Desmopressin||ND||ND||ND
|-
| Dexamethasone||No||ND||No
|-
| Dexfenfluramine||ND||ND||ND
|-
| Dexrazoxane||ND||ND||ND
|-
| Dezocine||ND||ND||ND
|-
| Diazepam||No||ND||U
|-
| Diazoxide||Yes||L||Yes
|-
| Dibekacin||Yes||L||ND
|-
| Diclofenac||U||ND||U
|-
| Dicloxacillin||No||ND||No
|-
| Didanosine||No||ND||No
|-
| Diethylpropion||ND||ND||ND
|-
| Diflunisal||No||ND||U
|-
| Digitoxin||No||ND||No
|-
| Digoxin||No||ND||No
|-
| Dihydroergotamine||ND||ND||ND
|-
| Diltiazem||No||ND||No
|-
| Diphenhydramine||U||ND||U
|-
| Diphenoxylate/Atropine||ND||ND||ND
|-
| Dipyridamole||U||ND||ND
|-
| Dirithromycin||No||ND||No
|-
| Disopyramide||Yes||L||ND
|-
| Dobutamine||No||ND||No
|-
| Docetaxel||U||ND||U
|-
| Dolasetron||ND||ND||ND
|-
| Donepezil||U||ND||U
|-
| Dopamine||No||ND||U
|-
| Doxacurium||No||ND||U
|-
| Doxazosin||No||ND||No
|-
| Doxepin||No||ND||No
|-
| Doxercalciferol||No||ND||U
|-
| Doxorubicin||No||ND||ND
|-
| Doxycycline||No||ND||No
|-
| Dronabinol||U||ND||U
|-
| Droperidol||U||ND||U
|-
| Edetate calcium (EDTA)||Yes||L||Yes
|-
| Efavirenz||U||ND||U
|-
| Enalapril (enalaprilat)||Yes||L||Yes
|-
| Encainide||No||ND||ND
|-
| Enoxacin||No||ND||No
|-
| Enoxaparin||No||ND||U
|-
| Ephedrine||ND||ND||ND
|-
| Epinephrine||ND||ND||ND
|-
| Epoetin alfa||No||ND||No
|-
| Epoprostenol||ND||ND||ND
|-
| Eprosartan||U||No||U
|-
| Eptifibatide||ND||ND||ND
|-
| Ergocalciferol||ND||ND||ND
|-
| Erythromycin||No||ND||No
|-
| Esmolol (ASL-8123)||Yes||L||Yes
|-
| Estazolam||U||ND||U
|-
| Ethacrynic acid||No||ND||U
|-
| Ethambutol||No||No||U
|-
| Ethchlorvynol||No||ND||No
|-
| Ethinyl estradiol||ND||ND||No
|-
| Ethosuximide||Yes||L||ND
|-
| Etodolac||No||ND||U
|-
| Etoposide||No||ND||No
|-
| Famciclovir (penciclovir)||Yes||L||ND
|-
| Famotidine||No||ND||No
|-
| Felbamate||ND||ND||ND
|-
| Felodipine||No||ND||U
|-
| Fenfluramine||ND||ND||ND
|-
| Fenofibrate||No||ND||U
|-
| Fenoldopam||U||ND||No
|-
| Fenoprofen||No||ND||U
|-
| Fentanyl||ND||ND||ND
|-
| Ferric gluconate||No||ND||U
|-
| Ferrous (iron) salts||U||ND||U
|-
| Fexofenadine||No||ND||U
|-
| Filgrastim||No||ND||U
|-
| Finasteride||U||ND||U
|-
| Flecainide||No||ND||U
|-
| Fleroxacin||No||No||No
|-
| Floxuridine||ND||ND||ND
|-
| Fluconazole||Yes||L||Yesa
|-
| Flucytosine||Yes||L||Yes
|-
| Fludarabine||ND||ND||ND
|-
| Flumazenil||ND||ND||ND
|-
| Fluorouracil||Yes||L||ND
|-
| Fluoxetine||No||ND||No
|-
| Fluphenazine||U||ND||U
|-
| Flurazepam||No||ND||U
|-
| Flurbiprofen||ND||ND||No
|-
| Flutamide||No||ND||U
|-
| Fluvastatin||U||ND||U
|-
| Fluvoxamine||U||ND||U
|-
| Fomepizole||Yes||L||ND
|-
| Foscarnet||Yes||Yes||ND
|-
| Fosfomycin||Yes||L||ND
|-
| Fosinopril (fosinoprilat)||No||ND||No
|-
| Fosphenytoin||U||ND||U
|-
| Furosemide||No||ND||U
|-
| Fusidic acid||No||ND||No
|-
| Gabapentin||Yes||L||ND
|-
| Gadodiamide||Yes||L||No
|-
| Gadoversetamide||ND||Yes||ND
|-
| Gallium||ND||ND||ND
|-
| Gallopamil||U||ND||U
|-
| Ganciclovir||Yes||L||ND
|-
| Ganirelix||ND||ND||ND
|-
| Gemcitabine||ND||ND||ND
|-
| Gemfibrozil||No||ND||No
|-
| Gentamicin||Yes||Yes||Yes
|-
| Glatiramer||ND||ND||ND
|-
| Glimepiride||U||ND||U
|-
| Glipizide||U||ND||U
|-
| Glucagon||U||ND||U
|-
| Glutethimide||No||ND||No
|-
| Glyburide||No||ND||U
|-
| Gold sodium thiomalate||No||ND||U
|-
| Granisetron||ND||ND||ND
|-
| Grepafloxacin||ND||ND||ND
|-
| Guanabenz||U||ND||ND
|-
| Guanadrel||ND||ND||ND
|-
| Guanethidine||ND||ND||ND
|-
| Guanfacine||No||ND||No
|-
| Halofantrine||ND||ND||ND
|-
| Haloperidol||No||ND||No
|-
| Heparin||No||ND||No
|-
| Hexobarbital||No||ND||U
|-
| Hirudin||No||No||ND
|-
| Hydralazine||No||ND||No
|-
| Hydrochlorothiazide||No||ND||U
|-
| Hydrocodone||ND||ND||ND
|-
| Hydrocortisone||U||ND||U
|-
| Hydromorphone||ND||ND||ND
|-
| Hydroxychloroquine||ND||ND||ND
|-
| Hydroxyurea||No||ND||U
|-
| Hydroxyzine||No||ND||No
|-
| Ibuprofen||No||ND||U
|-
| Ibutilide||ND||ND||ND
|-
| Idarubicin||U||ND||U
|-
| Ifosfamide||Yes||L||ND
|-
| Imipenem||Yes||L||Yes
|-
| Imipramine||No||ND||No
|-
| Immune globulin(human)||U||ND||U
|-
| Indapamide||No||ND||U
|-
| Indinavir||ND||ND||ND
|-
| Indomethacin||No||ND||U
|-
| Insulin||No||ND||No
|-
| Interferons||No||ND||No
|-
| Iodixanol||Yes||L||ND
|-
| Iopromide||Yes||Yes||ND
|-
| Irbesartan||No||ND||ND
|-
| Irinotecan (SN-38 metabolite)||U||ND||U
|-
| Iron dextran||No||ND||U
|-
| Isocarboxazid||ND||ND||ND
|-
| Isoniazid||No||No||U
|-
| Isoproterenol||ND||ND||ND
|-
| Isosorbide dinitrate||No||ND||No
|-
| Isosorbide mononitrate||Yes||L||No
|-
| Isradipine||No||ND||No
|-
| Itraconazole||No||ND||U
|-
| Kanamycin||Yes||L||Yes
|-
| Ketoconazole||No||ND||No
|-
| Ketoprofen||U||ND||U
|-
| Ketorolac||U||ND||U
|-
| Labetalol||No||ND||No
|-
| Lamivudine||No||ND||U
|-
| Lamotrigine||No||ND||U
|-
| Lansoprazole||No||ND||U
|-
| Leflunomide||No||ND||No
|-
| Letrozole||ND||ND||ND
|-
| Leuprolide||ND||ND||ND
|-
| Levamisole||ND||ND||ND
|-
| Levobupivacaine||U||ND||U
|-
| Levofloxacin||U||ND||U
|-
| Levonorgestrel||U||ND||U
|-
| Levorphanol||ND||ND||ND
|-
| Levothyroxine||U||ND||U
|-
| Lidocaine||No||ND||U
|-
| Lincomycin||No||ND||No
|-
| Lisinopril||Yes||L||ND
|-
| Lithium||Yes||L||Yes
|-
| Lomefloxacin||No||ND||No
|-
| Lomustine||No||ND||U
|-
| Loperamide||ND||ND||ND
|-
| Loracarbef||Yes||L||ND
|-
| Loratadine||No||ND||No
|-
| Lorazepam||No||ND||U
|-
| Losartan||No||ND||No
|-
| Lovastatin||U||ND||U
|-
| Loxapine||ND||ND||ND
|-
| Mangafodipir||ND||ND||ND
|-
| Mannitol||Yes||L||Yes
|-
| Maprotiline||No||ND||U
|-
| Mechlorethamine||No||ND||No
|-
| Meclofenamate||U||ND||U
|-
| Mefenamic acid||No||ND||U
|-
| Mefloquine||U||ND||U
|-
| Melphalan||No||ND||ND
|-
| Meperidine||No||ND||U
|-
| Meprobamate||Yes||L||Yes
|-
| Mercaptopurine||Yes||L||ND
|-
| Meropenem||Yes||L||ND
|-
| Mesalamine (5-ASA)||U||ND||U
|-
| Mesna||ND||ND||ND
|-
| Mesoridazine||U||ND||U
|-
| Metaproterenol||ND||ND||ND
|-
| Metformin||Yes||L||ND
|-
| Methadone||No||ND||No
|-
| Methaqualone||No||ND||No
|-
| Methenamine||ND||ND||ND
|-
| Methicillin||No||ND||No
|-
| Methimazole||No||ND||No
|-
| Methotrexate||Yes||Yes||No
|-
| Methyldopa||Yes||L||Yes
|-
| Methylphenidate||U||ND||U
|-
| Methylprednisolone||Yes||L||ND
|-
| Metoclopramide||No||ND||No
|-
| Metolazone||No||ND||U
|-
| Metoprolol||Yes||L||ND
|-
| Metronidazole||Yes||L||No
|-
| Mexiletine||Yes||L||No
|-
| Mezlocillin||Yes||L||No
|-
| Miacalcin||ND||ND||ND
|-
| Miconazole||No||ND||No
|-
| Midazolam||No||ND||U
|-
| Midodrine (de-glymidodrine)||Yes||ND||NA
|-
| Miglitol||ND||ND||ND
|-
| Milrinone||ND||ND||ND
|-
| Minocycline||No||ND||No
|-
| Minoxidil||Yes||L||Yes
|-
| Mirtazapine||U||ND||U
|-
| Misoprostol||U||ND||U
|-
| Mitomycin||ND||ND||ND
|-
| Mitoxantrone||No||ND||No
|-
| Mivacurium||ND||ND||ND
|-
| Modafinil||ND||ND||ND
|-
| Moexipril||ND||ND||ND
|-
| Molindone||U||ND||U
|-
| Montelukast||U||ND||U
|-
| Moricizine||U||ND||U
|-
| Morphine||Yes||ND||No
|-
| Muromonab-CD3||U||ND||U
|-
| Mycophenolate (mycophenolic acid)||No||ND||No
|-
| Nabumetone||No||ND||ND
|-
| Nadolol||Yes||L||ND
|-
| Nafcillin||No||ND||No
|-
| Nalmefene||No||ND||U
|-
| Naloxone||ND||ND||ND
|-
| Naltrexone||ND||ND||ND
|-
| Naproxen||No||ND||U
|-
| Naratriptan||ND||ND||ND
|-
| Nefazodone||U||ND||U
|-
| Nelfinavir||U||ND||U
|-
| Netilmicin||Yes||L||Yes
|-
| Nevirapine||ND||ND||ND
|-
| Nicardipine||No||ND||U
|-
| Nicotine||ND||ND||ND
|-
| Nicotinic acid||ND||ND||ND
|-
| Nifedipine||No||ND||No
|-
| Nilutamide||ND||ND||ND
|-
| Nimodipine||No||ND||No
|-
| Nisoldipine||No||ND||No
|-
| Nitrendipine||No||ND||U
|-
| Nitrofurantoin||Yes||L||ND
|-
| Nitroglycerin||No||ND||No
|-
| Nitroprusside||Yes||L||Yes
|-
| Nizatidine||No||ND||No
|-
| Nomifensine||ND||ND||ND
|-
| Norethindrone||ND||ND||No
|-
| Norfloxacin||No||ND||U
|-
| Nortriptyline||No||ND||No
|-
| Octreotide||Yes||L||ND
|-
| Ofloxacin||Yes||ND||No
|-
| Olanzapine||No||ND||No
|-
| Olsalazine||U||ND||U
|-
| Omapatrilat||No||ND||ND
|-
| Omeprazole||U||ND||U
|-
| Ondansetron||U||ND||U
|-
| Orbofiban||Yes||L||ND
|-
| Orlistat||U||ND||U
|-
| Ornidazole||Yes||L||No
|-
| Orphenadrine||ND||ND||ND
|-
| Oxacillin||No||ND||No
|-
| Oxaprozin||No||ND||U
|-
| Oxazepam||No||ND||U
|-
| Oxybutynin||ND||ND||ND
|-
| Oxycodone||ND||ND||ND
|-
| Oxymorphone||ND||ND||ND
|-
| Paclitaxel||No||ND||U
|-
| Pamidronate||ND||ND||ND
|-
| Pancuronium||ND||ND||ND
|-
| Pantoprazole||No||ND||ND
|-
| Paricalcitol||No||ND||ND
|-
| Paroxetine||No||ND||U
|-
| Pefloxacin||No||ND||No
|-
| Pegaspargase||U||ND||U
|-
| Pemoline||Yes||L||No
|-
| Penbutolol||No||ND||No
|-
| Penicillamine||Yes||L||ND
|-
| Pencillin G||Yes||L||No
|-
| Pentamidine||No||ND||No
|-
| Pentazocine||Yes||L||ND
|-
| Pentobarbital||No||ND||U
|-
| Pentosan polysulfate||ND||ND||ND
|-
| Pentostatin||ND||ND||ND
|-
| Pentoxifylline||U||ND||ND
|-
| Pergolide||U||ND||U
|-
| Perindopril (perindoprilat)||Yes||L||ND
|-
| Perphenazine||U||ND||U
|-
| Phenelzine||ND||ND||ND
|-
| Phenobarbital||Yes||L||Yes
|-
| Phentermine||ND||ND||ND
|-
| Phentolamine||ND||ND||ND
|-
| Phenylbutazone||No||ND||U
|-
| Phenylpropanolamine||ND||ND||ND
|-
| Phenytoin||No||Yes||No
|-
| Pimagedine (aminoguanidine)||Yes||ND||ND
|-
| Pimozide||ND||ND||ND
|-
| Pindolol||ND||ND||ND
|-
| Pioglitazone||U||ND||U
|-
| Piperacillin||Yes||L||No
|-
| Piroxicam||U||ND||U
|-
| Plicamycin||ND||ND||ND
|-
| Polythiazide||No||ND||No
|-
| Pralidoxime||ND||ND||ND
|-
| Pramipexole||No||ND||U
|-
| Pravastatin||No||ND||ND
|-
| Prazepam||No||ND||U
|-
| Prazosin||No||ND||No
|-
| Prednisone||No||ND||No
|-
| Primidone||Yes||L||ND
|-
| Probucol||No||ND||No
|-
| Procainamide||Yes||L||No
|-
| Procarbazine||ND||ND||ND
|-
| Prochlorperazine||U||ND||U
|-
| Promazine||U||ND||U
|-
| Promethazine||No||ND||ND
|-
| Propafenone||No||ND||No
|-
| Propofol||U||ND||U
|-
| Propoxyphene||No||ND||No
|-
| Propranolol||No||ND||No
|-
| Protriptyline||No||ND||No
|-
| Pseudoephedrine||No||ND||U
|-
| Pyrazinamide||Yes||Yes||No
|-
| Pyrimethamine||ND||ND||ND
|-
| Quazepam||U||ND||U
|-
| Quetiapine||ND||ND||ND
|-
| Quinapril (quinaprilat)||No||ND||No
|-
| Quinidine||No||ND||No
|-
| Quinine||No||ND||No
|-
| Quinupristin/dalfopristin||ND||ND||No
|-
| Rabeprazole||U||ND||U
|-
| Raloxifene||U||ND||U
|-
| Ramipril (ramiprilat)||No||ND||ND
|-
| Ranitidine||No||ND||No
|-
| Recainam||No||ND||U
|-
| Repaglinide||U||ND||U
|-
| Reserpine||No||ND||No
|-
| Reteplase||ND||ND||ND
|-
| Reviparin||No||ND||U
|-
| Rifabutin||U||ND||U
|-
| Rifampin||No||No||No
|-
| Rifapentine||U||ND||U
|-
| Rilmenidine||No||ND||U
|-
| Rimantadine||No||ND||U
|-
| Risperidone||ND||ND||ND
|-
| Ritodrine||Yes||L||Yes
|-
| Ritonavir||U||ND||U
|-
| Rizatriptan||ND||ND||ND
|-
| Rocuronium||ND||ND||ND
|-
| Rofecoxib||No||ND||U
|-
| Ropinirole||U||ND||U
|-
| Rosiglitazone||No||ND||U
|-
| Roxithromycin||ND||ND||No
|-
| Rufloxacin||ND||ND||ND
|-
| Salsalate||Yes||L||No
|-
| Saquinavir||U||ND||U
|-
| Sargramostim||ND||ND||ND
|-
| Secobarbital||No||ND||No
|-
| Selegiline||ND||ND||ND
|-
| Sermorelin||ND||ND||ND
|-
| Sertindole||No||ND||ND
|-
| Sertraline||No||ND||U
|-
| Sevelamer||U||U||U
|-
| Sibutramine||U||ND||U
|-
| Sildenafil||U||ND||U
|-
| Silver||No||ND||U
|-
| Simvastatin||U||ND||U
|-
| Sirolimus||U||ND||ND
|-
| Sisomicin||Yes||L||ND
|-
| Somatropin||U||ND||U
|-
| Sotalol||Yes||L||ND
|-
| Sparfloxacin||ND||ND||ND
|-
| Spectinomycin||Yes||L||Yes
|-
| Spirapril (spiraprilat)||U||ND||U
|-
| Spironolactone||U||ND||U
|-
| Stavudine||ND||ND||ND
|-
| Streptomycin||Yes||L||Yes
|-
| Streptozocin||ND||ND||ND
|-
| Sucralfate||No||ND||No
|-
| Sufentanil||U||ND||U
|-
| Sulbactam||Yes||L||No
|-
| Sulfamethoxazole||Yes||L||No
|-
| Sulfisoxazole||Yes||L||Yes
|-
| Sulindac||No||ND||U
|-
| Sumatriptan||ND||ND||ND
|-
| Tacrine||ND||ND||ND
|-
| Tacrolimus||No||ND||U
|-
| Tamoxifen||ND||ND||ND
|-
| Tamsulosin||U||ND||U
|-
| Tazobactam||Yes||L||No
|-
| Teicoplanin||No||ND||No
|-
| Telmisartan||U||ND||U
|-
| Temazepam||No||ND||U
|-
| Temocillin||Yes||L||No
|-
| Teniposide||U||ND||U
|-
| Terazosin||No||ND||No
|-
| Terbinafine||U||ND||U
|-
| Terbutaline||ND||ND||ND
|-
| Testosterone||U||ND||U
|-
| Tetracycline||No||ND||No
|-
| Thalidomide||ND||ND||ND
|-
| Theophylline||Yes||L||No
|-
| Thiethylperazine||ND||ND||ND
|-
| Thioguanine||ND||ND||ND
|-
| Thioridazine||U||ND||U
|-
| Thiotepa||ND||ND||ND
|-
| Thiothixene||U||ND||U
|-
| Tiagabine||No||ND||ND
|-
| Ticarcillin||Yes||L||No
|-
| Ticlopidine||U||ND||U
|-
| Tiludronate||U||ND||U
|-
| Timolol||No||ND||No
|-
| Tinidazole||Yes||L||ND
|-
| Tirofiban||Yes||L||ND
|-
| Tizanidine||ND||ND||ND
|-
| Tobramycin||Yes||L||Yes
|-
| Tocainide||Yes||L||ND
|-
| Tolazamide||U||ND||U
|-
| Tolbutamide||No||ND||U
|-
| Tolcapone||U||ND||ND
|-
| Tolmetin||U||ND||U
|-
| Tolterodine||U||ND||U
|-
| Topiramate||Yes||L||ND
|-
| Topotecan||ND||ND||ND
|-
| Torsemide||No||ND||U
|-
| Tramadol||No||ND||U
|-
| Trandolapril (trandolaprilat)||Yes||L||ND
|-
| Tranexamic acid||ND||ND||ND
|-
| Tranylcypromine||ND||ND||ND
|-
| Trapidil||ND||ND||ND
|-
| Trazodone||U||ND||U
|-
| Tretinoin||ND||ND||ND
|-
| Triamterene||ND||ND||ND
|-
| Triazolam||No||ND||U
|-
| Trifluoperazine||No||ND||No
|-
| Triflupromazine||U||ND||U
|-
| Trihexyphenidyl||ND||ND||ND
|-
| Trimethoprim||Yes||L||No
|-
| Trimetrexate||U||ND||U
|-
| Trimipramine||U||ND||U
|-
| Troglitazone||U||ND||U
|-
| Tropisetron||U||ND||U
|-
| Trovafloxacin||No||ND||ND
|-
| Ursodiol||U||ND||U
|-
| Valacyclovir||Yes||L||ND
|-
| Valproic acid||No||ND||No
|-
| Valsartan||U||ND||U
|-
| Vancomycin||No||Yes||No
|-
| Vecuronium||U||ND||U
|-
| Venlafaxine||No||ND||U
|-
| Verapamil||No||ND||No
|-
| Vigabatrin||Yes||L||ND
|-
| Vinblastine||ND||ND||ND
|-
| Vincristine||ND||ND||ND
|-
| Warfarin||No||ND||No
|-
| Zafirlukast||U||ND||U
|-
| Zalcitabine||ND||ND||ND
|-
| Zidovudine/GZDV||No/Yes||ND/L||No/Yes
|-
| Zileuton||No||ND||U
|-
| Zolmitriptan||ND||ND||ND
|-
| Zolpidem||No||ND||U
|}
'''Yes'''- dialyzable, '''No'''-not dialyzable, '''U'''-unlikely, '''L'''-likely but no data, '''ND'''-no data, '''NS'''- no high permeability membrane specified


==See Also==
==See Also==
*[[Dialysis]]
*[[In-Training Exam Review]]


==References==
==References==
<references/>
<references/>


[[Category:Tox]]
[[Category:Toxicology]]

Latest revision as of 23:23, 27 February 2022

Background

Factors Influencing Dialyzability

Molecular weight

  • Smaller molecular weight substances will pass through the dialysis membrane more easily than larger molecular weights.

Protein Binding

  • Drugs with a high degree of protein binding will have a small plasma concentration of unbound drug available for dialysis, making them poorly dialyzable or requiring multiple sessions.

Volume of Distribution

  • Drugs with large volumes of distribution usually due to lipid solubility and low plasma protein binding are poorly diliazable.

Plasma clearance

  • Although plasma clearance may be beneficial, increasing plasma clearance will dcrease dialysis clearance.

Dialysis Flow Rates

  • Greater degrees of dialysis can be achieved with faster dialysate flow rates if the dialysate drug concentrations is low. As the concentration of drug is increased in the diasylate the flow rate needs to be lowered.

Common Dialyzable Drugs

Mnemonics BLISTMED and ISTUMBLED:



See Also

References

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