Difference between revisions of "Delirium tremens"

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Revision as of 16:03, 22 March 2016

Background

  • Onset after last drink - 48 to 96hrs

Clinical Features

  • Delirium
    • Disconnected from the environment
  • Hyperdynamic vital signs
  • Febrile

Differential Diagnosis

Altered mental status

Diffuse brain dysfunction

Primary CNS disease or trauma

Psychiatric

General Psychiatric

Diagnosis

Management

  • Goal = sleepy, but arousable w/ HR <110
  • Diazepam
    • Long duration of action, max effect within 5min
    • Start 10mg IV
      • Redose q5min after observing effect
      • Can double subsequent doses until achieve goal
  • Propofol
    • Consider intubation + propofol drip if benzo-nonresponsive
  • Thiamine 100mg

Special Situations

  • The propylene glycol diluent in lorazepam, phenobarbital and diazepam, may induce a hyperosmolar anion gap metabolic acidosis if given as a drip in high doses ≥ 48hrs.[1] Consider alternatives such as propofol or dexmedetomidine if patients need long term sedation for Delirum Tremens

Disposition

Admit

See Also

External Links

References

  1. Arroliga AC, Shehab N, McCarthy K, Gonzales JP. Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults*. Critical Care Medicine. 2004;32(8):1709–1714. doi:10.1097/01.CCM.0000134831.40466.39.