Deferoxamine

General

• Type:
• Dosage Forms:
• Routes of Administration:
• Common Trade Names:

Adult Dosing

Iron toxicity

• 1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
• Subsequent doses are 500mg increments guided by clinical status of patient / urine color
• Recommended amount during first 24hr is 360mg/kg not to exceed 6g.

Special Populations

• Pregnancy Rating:
• Lactation risk:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Indications

• Systemic toxicity and iron level > 350 mcg/dL
• Metabolic acidosis
• Progressive symptoms
• Serum iron level >500 mcg/dL

Contraindications

• Allergy to class/drug
• Renal failure patients not on hemodialysis

Adverse Reactions

• Hypotension (pre-existing hypotension is NOT a contraindication to therapy)
• ARDS
• Yersinia enterocolitica sepsis
• Can see "vin rose" colored urine from chelated iron extretion

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Comments

• Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.