Dapsone

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Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

Hansen's disease (leprosy)

  • paucibacillary: 100mg PO QD x6mo
    • Use with rifampin
  • multibacillary: 100mg PO QD x12mo
    • Use with rifampin, clofazimine

Bullous pemphigoid

Dermatitis herpetiformis

  • 50mg PO QD

PCP

  • Prophylaxis: 100mg/day PO divided QD-bid
    • Off label use
  • Treatment: 100mg PO QD x21 days

Malaria suppression

Toxoplasmosis prophylaxis

  • 50mg PO QD
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular function

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References