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Administration
- Type: Antibiotic
- Dosage Forms: 25,100
- Routes of Administration: Oral
Adult Dosing
- Hansen disease (leprosy)
- paucibacillary: 100mg PO QD x6mo
- multibacillary: 100mg PO QD x12mo
- Use with rifampin, clofazimine
- Dermatitis herpetiformis: 50mg PO QD
- PCP prophylaxis: 100mg/day PO divided QD-bid
- PCP treatment: 100mg PO QD x21 days
- Not 1st-line agent; use with trimethoprim
- Off label use
- Malaria suppression: 100mg PO qwk
- Use with pyrimethamine
- Off label use
Pediatric Dosing
Special Populations
Renal Dosing
Hepatic Dosing
- Caution advised with hepatic impairment
- CBC qwk x4, qmo x6, then q6mo thereafter
- LFTs at baseline, then periodically
Contraindications
- Allergy to class/drug
- caution if renal or hepatic impairment
- caution if impaired cardiovascular function
Adverse Reactions
Serious
- anemia, hemolytic
- aplastic anemia
- agranulocytosis
- exfoliative dermatitis
- erythema multiforme
- toxic epidermal necrolysis
Common
- fever
- myalgia
- headache
- rigors
- fatigue
- malaise
- dizziness
Pharmacology
- Half-life: 28 hrs
- Metabolism: Liver, CYP450
- Excretion: Urine
Mechanism of Action
See Also
References