Difference between revisions of "Dapsone"

(References)
(Text replacement - " w/ " to " with ")
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*Hansen disease (leprosy)
 
*Hansen disease (leprosy)
 
**paucibacillary: 100 mg PO qd x6mo
 
**paucibacillary: 100 mg PO qd x6mo
***Use w/ rifampin
+
***Use with rifampin
 
**multibacillary: 100 mg PO qd x12mo
 
**multibacillary: 100 mg PO qd x12mo
***Use w/ rifampin, clofazimine
+
***Use with rifampin, clofazimine
  
 
*Dermatitis herpetiformis: 50 mg PO qd
 
*Dermatitis herpetiformis: 50 mg PO qd
Line 17: Line 17:
  
 
*PCP tx: 100 mg PO qd x21 days
 
*PCP tx: 100 mg PO qd x21 days
**Not 1st-line agent; use w/ trimethoprim
+
**Not 1st-line agent; use with trimethoprim
 
**Off label use
 
**Off label use
  
 
*Malaria suppression: 100 mg PO qwk
 
*Malaria suppression: 100 mg PO qwk
**Use w/ pyrimethamine
+
**Use with pyrimethamine
 
**Off label use
 
**Off label use
  

Revision as of 02:32, 15 July 2016

Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

  • Hansen disease (leprosy)
    • paucibacillary: 100 mg PO qd x6mo
      • Use with rifampin
    • multibacillary: 100 mg PO qd x12mo
      • Use with rifampin, clofazimine
  • Dermatitis herpetiformis: 50 mg PO qd
  • PCP prophylaxis: 100 mg/day PO divided qd-bid
    • Off label use
  • PCP tx: 100 mg PO qd x21 days
    • Not 1st-line agent; use with trimethoprim
    • Off label use
  • Malaria suppression: 100 mg PO qwk
    • Use with pyrimethamine
    • Off label use
  • Toxoplasmosis prophylaxis: 50 mg PO qd
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular function

Adverse Reactions

Serious

  • anemia, hemolytic
  • aplastic anemia
  • agranulocytosis
  • exfoliative dermatitis
  • erythema multiforme
  • toxic epidermal necrolysis

Common

  • fever
  • myalgia
  • headache
  • rigors
  • fatigue
  • malaise
  • dizziness

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References