Difference between revisions of "Dapsone"

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==Special Populations==
 
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]:
+
*[[Lactation risk categories|Lactation risk]]: Probably unsafe
 
===Renal Dosing===
 
===Renal Dosing===
 
*No adjustment
 
*No adjustment
 
===Hepatic Dosing===
 
===Hepatic Dosing===
 
*Caution advised with hepatic impairment
 
*Caution advised with hepatic impairment
 +
*CBC qwk x4, qmo x6, then q6mo thereafter
 +
*LFTs at baseline, then periodically
  
 
==Contraindications==
 
==Contraindications==

Revision as of 19:56, 25 January 2016

Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

  • Hansen dz (leprosy)
    • paucibacillary: 100 mg PO qd x6mo
      • Use w/ rifampin
    • multibacillary: 100 mg PO qd x12mo
      • Use w/ rifampin, clofazimine
  • Dermatitis herpetiformis: 50 mg PO qd
  • PCP prophylaxis: 100 mg/day PO divided qd-bid
    • Off label use
  • PCP tx: 100 mg PO qd x21 days
    • Not 1st-line agent; use w/ trimethoprim
    • Off label use
  • Malaria suppression: 100 mg PO qwk
    • Use w/ pyrimethamine
    • Off label use
  • Toxoplasmosis prophylaxis: 50 mg PO qd
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular fxn

Adverse Reactions

Serious

  • anemia, hemolytic
  • aplastic anemia
  • agranulocytosis
  • exfoliative dermatitis
  • erythema multiforme
  • toxic epidermal necrolysis

Common

  • fever
  • myalgia
  • headache
  • rigors
  • fatigue
  • malaise
  • dizziness

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References

<Epocrates, UpToDate>