Difference between revisions of "Dapsone"
(Dapsone page) |
(Dapsone edits) |
||
| Line 7: | Line 7: | ||
*Hansen dz (leprosy) | *Hansen dz (leprosy) | ||
**paucibacillary: 100 mg PO qd x6mo | **paucibacillary: 100 mg PO qd x6mo | ||
| − | **Use w/ rifampin | + | ***Use w/ rifampin |
**multibacillary: 100 mg PO qd x12mo | **multibacillary: 100 mg PO qd x12mo | ||
| − | **Use w/ rifampin, clofazimine | + | ***Use w/ rifampin, clofazimine |
*Dermatitis herpetiformis: 50 mg PO qd | *Dermatitis herpetiformis: 50 mg PO qd | ||
| Line 18: | Line 18: | ||
*PCP tx: 100 mg PO qd x21 days | *PCP tx: 100 mg PO qd x21 days | ||
**Not 1st-line agent; use w/ trimethoprim | **Not 1st-line agent; use w/ trimethoprim | ||
| + | **Off label use | ||
*Malaria suppression: 100 mg PO qwk | *Malaria suppression: 100 mg PO qwk | ||
**Use w/ pyrimethamine | **Use w/ pyrimethamine | ||
| + | **Off label use | ||
*Toxoplasmosis prophylaxis: 50 mg PO qd | *Toxoplasmosis prophylaxis: 50 mg PO qd | ||
| + | **Off label use | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 12:56, 20 January 2016
Contents
Administration
- Type: Antibiotic
- Dosage Forms: 25,100
- Routes of Administration: Oral
Adult Dosing
- Hansen dz (leprosy)
- paucibacillary: 100 mg PO qd x6mo
- Use w/ rifampin
- multibacillary: 100 mg PO qd x12mo
- Use w/ rifampin, clofazimine
- paucibacillary: 100 mg PO qd x6mo
- Dermatitis herpetiformis: 50 mg PO qd
- PCP prophylaxis: 100 mg/day PO divided qd-bid
- Off label use
- PCP tx: 100 mg PO qd x21 days
- Not 1st-line agent; use w/ trimethoprim
- Off label use
- Malaria suppression: 100 mg PO qwk
- Use w/ pyrimethamine
- Off label use
- Toxoplasmosis prophylaxis: 50 mg PO qd
- Off label use
Pediatric Dosing
Special Populations
Renal Dosing
- No adjustment
Hepatic Dosing
- Caution advised with hepatic impairment
Contraindications
- Allergy to class/drug
- caution if renal or hepatic impairment
- caution if impaired cardiovascular fxn
Adverse Reactions
Serious
- anemia, hemolytic
- aplastic anemia
- agranulocytosis
- exfoliative dermatitis
- erythema multiforme
- toxic epidermal necrolysis
Common
- fever
- myalgia
- headache
- rigors
- fatigue
- malaise
- dizziness
Pharmacology
- Half-life: 28 hrs
- Metabolism: Liver, CYP450
- Excretion: Urine
Mechanism of Action
Comments
See Also
References
<Epocrates, UpToDate>