Difference between revisions of "Dapsone"

(Adult Dosing)
 
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==Administration==
 
==Administration==
*Type: Antibiotic
+
*Type: [[Antibiotic]]
 
*Dosage Forms: 25,100
 
*Dosage Forms: 25,100
 
*Routes of Administration: Oral
 
*Routes of Administration: Oral
  
 
==Adult Dosing==
 
==Adult Dosing==
*Hansen disease (leprosy)
+
===[[Hansen's disease]] ([[leprosy]])===
**paucibacillary: 100 mg PO qd x6mo
+
*paucibacillary: 100mg PO QD x6mo
***Use w/ rifampin
+
**Use with rifampin
**multibacillary: 100 mg PO qd x12mo
+
*multibacillary: 100mg PO QD x12mo
***Use w/ rifampin, clofazimine
+
**Use with rifampin, clofazimine
  
*Dermatitis herpetiformis: 50 mg PO qd
+
===[[Bullous pemphigoid]]===
 +
*50mg PO QD
 +
**Use with topical or systemic [[corticosteroids]]
  
*PCP prophylaxis: 100 mg/day PO divided qd-bid
+
===Dermatitis herpetiformis===
 +
*50mg PO QD
 +
 
 +
===[[Pneumocystis jirovecii pneumonia|PCP]]===
 +
*Prophylaxis: 100mg/day PO divided QD-bid
 
**Off label use
 
**Off label use
 
+
*Treatment: 100mg PO QD x21 days
*PCP tx: 100 mg PO qd x21 days
+
**Not 1st-line agent; use with [[trimethoprim]]
**Not 1st-line agent; use w/ trimethoprim
 
 
**Off label use
 
**Off label use
  
*Malaria suppression: 100 mg PO qwk
+
===[[Malaria]] suppression===
**Use w/ pyrimethamine
+
*100mg PO qwk
 +
**Use with [[pyrimethamine]]
 
**Off label use
 
**Off label use
  
*Toxoplasmosis prophylaxis: 50 mg PO qd
+
===[[Toxoplasmosis]] prophylaxis===
 +
*50mg PO QD
 
**Off label use
 
**Off label use
  
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*Allergy to class/drug
 
*Allergy to class/drug
 
*caution if renal or hepatic impairment
 
*caution if renal or hepatic impairment
*caution if impaired cardiovascular fxn
+
*caution if impaired cardiovascular function
  
 
==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
*anemia, hemolytic
+
*[[anemia]], hemolytic
*aplastic anemia
+
*[[aplastic anemia]]
 
*agranulocytosis
 
*agranulocytosis
 
*exfoliative dermatitis
 
*exfoliative dermatitis
*erythema multiforme
+
*[[erythema multiforme]]
*toxic epidermal necrolysis
+
*[[toxic epidermal necrolysis]]
 +
 
 
===Common===
 
===Common===
*fever
+
*[[fever]]
 
*myalgia
 
*myalgia
*headache
+
*[[headache]]
 
*rigors
 
*rigors
 
*fatigue
 
*fatigue
 
*malaise
 
*malaise
*dizziness
+
*[[dizziness]]
  
 
==Pharmacology==
 
==Pharmacology==
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==References==
 
==References==
<Epocrates, UpToDate>
+
[[Category:Pharmacology]] [[Category:ID]]
[[Category:Pharmacology]]
 

Latest revision as of 23:51, 20 September 2019

Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

Hansen's disease (leprosy)

  • paucibacillary: 100mg PO QD x6mo
    • Use with rifampin
  • multibacillary: 100mg PO QD x12mo
    • Use with rifampin, clofazimine

Bullous pemphigoid

Dermatitis herpetiformis

  • 50mg PO QD

PCP

  • Prophylaxis: 100mg/day PO divided QD-bid
    • Off label use
  • Treatment: 100mg PO QD x21 days

Malaria suppression

Toxoplasmosis prophylaxis

  • 50mg PO QD
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular function

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References