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==Administration==
==Administration==
*Type: Antibiotic
*Type: [[Antibiotic]]
*Dosage Forms: 25,100
*Dosage Forms: 25,100
*Routes of Administration: Oral
*Routes of Administration: Oral


==Adult Dosing==
==Adult Dosing==
*Hansen disease (leprosy)
===[[Hansen's disease]] ([[leprosy]])===
**paucibacillary: 100mg PO qd x6mo
*paucibacillary: 100mg PO QD x6mo
***Use with rifampin
**Use with rifampin
**multibacillary: 100mg PO qd x12mo
*multibacillary: 100mg PO QD x12mo
***Use with rifampin, clofazimine
**Use with rifampin, clofazimine


*Dermatitis herpetiformis: 50mg PO qd
===[[Bullous pemphigoid]]===
*50mg PO QD
**Use with topical or systemic [[corticosteroids]]


*PCP prophylaxis: 100mg/day PO divided qd-bid
===Dermatitis herpetiformis===
*50mg PO QD
 
===[[Pneumocystis jirovecii pneumonia|PCP]]===
*Prophylaxis: 100mg/day PO divided QD-bid
**Off label use
**Off label use
 
*Treatment: 100mg PO QD x21 days
*PCP treatment: 100mg PO qd x21 days
**Not 1st-line agent; use with [[trimethoprim]]
**Not 1st-line agent; use with trimethoprim
**Off label use
**Off label use


*Malaria suppression: 100mg PO qwk
===[[Malaria]] suppression===
**Use with pyrimethamine
*100mg PO qwk
**Use with [[pyrimethamine]]
**Off label use
**Off label use


*[[Toxoplasmosis]] prophylaxis: 50mg PO qd
===[[Toxoplasmosis]] prophylaxis===
*50mg PO QD
**Off label use
**Off label use


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==Adverse Reactions==
==Adverse Reactions==
===Serious===
===Serious===
*anemia, hemolytic
*[[anemia]], hemolytic
*aplastic anemia
*[[aplastic anemia]]
*agranulocytosis
*agranulocytosis
*exfoliative dermatitis
*exfoliative dermatitis
*erythema multiforme
*[[erythema multiforme]]
*toxic epidermal necrolysis
*[[toxic epidermal necrolysis]]
 
===Common===
===Common===
*fever
*[[fever]]
*myalgia
*myalgia
*headache
*[[headache]]
*rigors
*rigors
*fatigue
*fatigue
*malaise
*malaise
*dizziness
*[[dizziness]]


==Pharmacology==
==Pharmacology==
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==References==
==References==
[[Category:Pharmacology]]
[[Category:Pharmacology]] [[Category:ID]]

Latest revision as of 23:51, 20 September 2019

Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

Hansen's disease (leprosy)

  • paucibacillary: 100mg PO QD x6mo
    • Use with rifampin
  • multibacillary: 100mg PO QD x12mo
    • Use with rifampin, clofazimine

Bullous pemphigoid

Dermatitis herpetiformis

  • 50mg PO QD

PCP

  • Prophylaxis: 100mg/day PO divided QD-bid
    • Off label use
  • Treatment: 100mg PO QD x21 days

Malaria suppression

Toxoplasmosis prophylaxis

  • 50mg PO QD
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular function

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References