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==Administration== | ==Administration== | ||
*Type: Antibiotic | *Type: [[Antibiotic]] | ||
*Dosage Forms: 25,100 | *Dosage Forms: 25,100 | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Hansen's disease]] ([[leprosy]])=== | |||
*paucibacillary: 100mg PO QD x6mo | |||
**Use with rifampin | |||
*multibacillary: 100mg PO QD x12mo | |||
**Use with rifampin, clofazimine | |||
* | ===[[Bullous pemphigoid]]=== | ||
*50mg PO QD | |||
**Use with topical or systemic [[corticosteroids]] | |||
*PCP | ===Dermatitis herpetiformis=== | ||
*50mg PO QD | |||
===[[Pneumocystis jirovecii pneumonia|PCP]]=== | |||
*Prophylaxis: 100mg/day PO divided QD-bid | |||
**Off label use | **Off label use | ||
*Treatment: 100mg PO QD x21 days | |||
* | **Not 1st-line agent; use with [[trimethoprim]] | ||
**Not 1st-line agent; use with trimethoprim | |||
**Off label use | **Off label use | ||
===[[Malaria]] suppression=== | |||
**Use with pyrimethamine | *100mg PO qwk | ||
**Use with [[pyrimethamine]] | |||
**Off label use | **Off label use | ||
===[[Toxoplasmosis]] prophylaxis=== | |||
*50mg PO QD | |||
**Off label use | **Off label use | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*anemia, hemolytic | *[[anemia]], hemolytic | ||
*aplastic anemia | *[[aplastic anemia]] | ||
*agranulocytosis | *agranulocytosis | ||
*exfoliative dermatitis | *exfoliative dermatitis | ||
*erythema multiforme | *[[erythema multiforme]] | ||
*toxic epidermal necrolysis | *[[toxic epidermal necrolysis]] | ||
===Common=== | ===Common=== | ||
*fever | *[[fever]] | ||
*myalgia | *myalgia | ||
*headache | *[[headache]] | ||
*rigors | *rigors | ||
*fatigue | *fatigue | ||
*malaise | *malaise | ||
*dizziness | *[[dizziness]] | ||
==Pharmacology== | ==Pharmacology== | ||
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==References== | ==References== | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] [[Category:ID]] |
Latest revision as of 23:51, 20 September 2019
Administration
- Type: Antibiotic
- Dosage Forms: 25,100
- Routes of Administration: Oral
Adult Dosing
Hansen's disease (leprosy)
- paucibacillary: 100mg PO QD x6mo
- Use with rifampin
- multibacillary: 100mg PO QD x12mo
- Use with rifampin, clofazimine
Bullous pemphigoid
- 50mg PO QD
- Use with topical or systemic corticosteroids
Dermatitis herpetiformis
- 50mg PO QD
PCP
- Prophylaxis: 100mg/day PO divided QD-bid
- Off label use
- Treatment: 100mg PO QD x21 days
- Not 1st-line agent; use with trimethoprim
- Off label use
Malaria suppression
- 100mg PO qwk
- Use with pyrimethamine
- Off label use
Toxoplasmosis prophylaxis
- 50mg PO QD
- Off label use
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation risk: Probably unsafe
Renal Dosing
- No adjustment
Hepatic Dosing
- Caution advised with hepatic impairment
- CBC qwk x4, qmo x6, then q6mo thereafter
- LFTs at baseline, then periodically
Contraindications
- Allergy to class/drug
- caution if renal or hepatic impairment
- caution if impaired cardiovascular function
Adverse Reactions
Serious
- anemia, hemolytic
- aplastic anemia
- agranulocytosis
- exfoliative dermatitis
- erythema multiforme
- toxic epidermal necrolysis
Common
Pharmacology
- Half-life: 28 hrs
- Metabolism: Liver, CYP450
- Excretion: Urine