Difference between revisions of "Dapsone"

(Adult Dosing)
(Text replacement - "qd" to "QD")
Line 6: Line 6:
 
==Adult Dosing==
 
==Adult Dosing==
 
*Hansen disease (leprosy)
 
*Hansen disease (leprosy)
**paucibacillary: 100mg PO qd x6mo
+
**paucibacillary: 100mg PO QD x6mo
 
***Use with rifampin
 
***Use with rifampin
**multibacillary: 100mg PO qd x12mo
+
**multibacillary: 100mg PO QD x12mo
 
***Use with rifampin, clofazimine
 
***Use with rifampin, clofazimine
  
*Dermatitis herpetiformis: 50mg PO qd
+
*Dermatitis herpetiformis: 50mg PO QD
  
*PCP prophylaxis: 100mg/day PO divided qd-bid
+
*PCP prophylaxis: 100mg/day PO divided QD-bid
 
**Off label use
 
**Off label use
  
*PCP treatment: 100mg PO qd x21 days
+
*PCP treatment: 100mg PO QD x21 days
 
**Not 1st-line agent; use with trimethoprim
 
**Not 1st-line agent; use with trimethoprim
 
**Off label use
 
**Off label use
Line 24: Line 24:
 
**Off label use
 
**Off label use
  
*[[Toxoplasmosis]] prophylaxis: 50mg PO qd
+
*[[Toxoplasmosis]] prophylaxis: 50mg PO QD
 
**Off label use
 
**Off label use
  

Revision as of 08:59, 7 July 2017

Administration

  • Type: Antibiotic
  • Dosage Forms: 25,100
  • Routes of Administration: Oral

Adult Dosing

  • Hansen disease (leprosy)
    • paucibacillary: 100mg PO QD x6mo
      • Use with rifampin
    • multibacillary: 100mg PO QD x12mo
      • Use with rifampin, clofazimine
  • Dermatitis herpetiformis: 50mg PO QD
  • PCP prophylaxis: 100mg/day PO divided QD-bid
    • Off label use
  • PCP treatment: 100mg PO QD x21 days
    • Not 1st-line agent; use with trimethoprim
    • Off label use
  • Malaria suppression: 100mg PO qwk
    • Use with pyrimethamine
    • Off label use

Pediatric Dosing

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Caution advised with hepatic impairment
  • CBC qwk x4, qmo x6, then q6mo thereafter
  • LFTs at baseline, then periodically

Contraindications

  • Allergy to class/drug
  • caution if renal or hepatic impairment
  • caution if impaired cardiovascular function

Adverse Reactions

Serious

  • anemia, hemolytic
  • aplastic anemia
  • agranulocytosis
  • exfoliative dermatitis
  • erythema multiforme
  • toxic epidermal necrolysis

Common

  • fever
  • myalgia
  • headache
  • rigors
  • fatigue
  • malaise
  • dizziness

Pharmacology

  • Half-life: 28 hrs
  • Metabolism: Liver, CYP450
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References