Dantrolene

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Administration

  • Type: Skeletal muscle relaxant
  • Dosage Forms:
  • Routes of Administration: IV, oral
  • Common Trade Names: Dantrium

Adult Dosing

Neuroleptic malignant syndrome

  • 0.25-2mg/kg IV q6-12hr
  • Max dose 10mg/kg/day

Pediatric Dosing

  • Same as above

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: contraindicated in acute hepatitis or active cirrhosis

Contraindications

  • Allergy to class/drug
  • Acute hepatitis or active cirrhosis

Adverse Reactions

Serious

  • Hepatotoxicity
  • GI bleed
  • Aplastic anemia, leukopenia, thrombocytopenia, small lymphocytic lymphoma
  • Muscle weakness, dysphagia, reduced vital capacity, dyspnea

Common

  • Flushing
  • Somnolence, fatigue, malaise
  • Nausea, diarrhea

Pharmacology

  • Half-life: 10.8h
  • Metabolism: Hepatic
  • Excretion:

Mechanism of Action

  • Interferes with release of calcium ions from sarcoplasmic reticulum in skeletal muscle, which results in dissociation of the excitation-contraction coupling

Comments

See Also

References