Dabigatran reversal


  • If aPTT is totally normal (<1.5x), unlikely that significant drug effect is present

Reversal Protocol

  1. Mild Bleeding
    1. Local control measures
    2. Delay next 1-2 dose OR discontinue as appropriate
  2. Moderate-Severe Bleeding
    1. Local control measures/surgical intervention
    2. Symptomatic treatment
    3. Fluids/blood/monitoring
    4. Oral charcoal administration (if taken <2hrs before)
    5. Hemodialysis (removes 60% over 2-3hrs)
  3. Life-Threatening Bleeding
    1. All above
    2. Consider
      1. rFVIIa
      2. PCC


Hennipin County Guidelines University of Utah Healthcare Thrombosis Service Guidelines