D-dimer: Difference between revisions
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==Differential Diagnosis== | |||
*'''Factors that can cause false-negative D-dimer''' | *'''Factors that can cause false-negative D-dimer''' | ||
**Symptoms of PE > 3 days | **Symptoms of [[PE]] > 3 days | ||
**Small PE | **Small [[PE]] | ||
**Use of qualitative latex fixation test | **Use of qualitative latex fixation test | ||
**Use of anticoagulants | **Use of anticoagulants | ||
| Line 8: | Line 9: | ||
**Cancer and malignancy | **Cancer and malignancy | ||
**Recent surgery | **Recent surgery | ||
**Infection (eg, | **Infection (eg, [[pneumonia]], [[sepsis]]) | ||
**Pregnancy | **[[Pregnancy]] | ||
**Age > 70 years | **Age > 70 years | ||
**DIC | **[[DIC]] | ||
**Trauma | **Trauma | ||
**Arterial thrombosis | **Arterial thrombosis | ||
**ACS/AMI | **[[ACS]]/AMI | ||
**Vaso-occlusive sickle cell crisis | **Vaso-occlusive [[sickle cell crisis]] | ||
**Acute CVA | **Acute [[CVA]] | ||
**Vasculitis | **Vasculitis | ||
**Superficial phlebitis | **Superficial [[phlebitis]] | ||
==Evaluation== | |||
*Traditional cutoff value = 500 | |||
*Age-adjusted (for over 50 years old) = age x 10 | |||
**Maintains high sensitivity while increasing specificity<ref>Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.</ref> | |||
==See Also== | ==See Also== | ||
[[Pulmonary | *[[Pulmonary embolism]] | ||
*[[Deep venous thrombosis]] | |||
==External Links== | |||
*[http://www.ncbi.nlm.nih.gov/pubmed/22284935 D-dimer threshold increase. Kline et. al.] | |||
==External Links== | |||
*[http://pemplaybook.org/podcast/big-labs-little-people-troponin-bnp-d-dimer-and-lactate/ Pediatric Emergency Playbook Podcast: Big Labs, Little People] | |||
== | ==References== | ||
<references/> | |||
[[Category: | [[Category:Cardiology]] | ||
[[Category: | [[Category:Pulmonary]] | ||
[[Category:Vascular]] | |||
Revision as of 04:16, 6 July 2017
Differential Diagnosis
- Factors that can cause false-negative D-dimer
- Factors that can cause false-positive D-dimer
Evaluation
- Traditional cutoff value = 500
- Age-adjusted (for over 50 years old) = age x 10
- Maintains high sensitivity while increasing specificity[1]
See Also
External Links
External Links
References
- ↑ Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.