Coagulopathy (main): Difference between revisions
(Text replacement - "==References== " to "==References== <references/> ") |
ClaireLewis (talk | contribs) No edit summary |
||
Line 5: | Line 5: | ||
==Clinical Features== | ==Clinical Features== | ||
*Spontaneous bleeding | *Spontaneous [[hemorrhage|bleeding]] | ||
*Bleeding out of proportion | *Bleeding out of proportion | ||
*Swollen joints | *Swollen joints | ||
*[[Epistaxis]] | *[[Epistaxis]] | ||
*Bleeding gums | *Bleeding gums | ||
*Menometrorrhagia | *[[vaginal Bleed Non-Pregnant|Menometrorrhagia]] | ||
*Easy bruising/petechiae | *Easy bruising/[[petechiae]] | ||
*Hematuria | *[[Hematuria]] | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Line 19: | Line 19: | ||
===Increased Clotting=== | ===Increased Clotting=== | ||
*[[Disseminated Intravascular Coagulation (DIC)]] | *[[Disseminated Intravascular Coagulation (DIC)]] | ||
== | |||
==Management== | |||
*[[Bleeding Treatments]] | *[[Bleeding Treatments]] | ||
*[[Procedures in patients with coagulopathies]] | *[[Procedures in patients with coagulopathies]] |
Revision as of 00:16, 1 October 2019
Background
- Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
- Secondary hemostasis: coagulation cascade
Clinical Features
- Spontaneous bleeding
- Bleeding out of proportion
- Swollen joints
- Epistaxis
- Bleeding gums
- Menometrorrhagia
- Easy bruising/petechiae
- Hematuria
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Increased Clotting
Management
- Bleeding Treatments
- Procedures in patients with coagulopathies
- Anticoagulant reversal (known medications)
- Anti-platelet agent reversal