Difference between revisions of "Coagulopathy (main)"

(Managment)
 
(12 intermediate revisions by 5 users not shown)
Line 1: Line 1:
 +
==Background==
 +
*Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
 +
*Secondary hemostasis: coagulation cascade
 +
[[File:Coagulation cascade.png|thumbnail|Coagulation cascade]]
 +
 +
==Clinical Features==
 +
*Spontaneous [[hemorrhage|bleeding]]
 +
*Bleeding out of proportion
 +
*Swollen joints
 +
*[[Epistaxis]]
 +
*Bleeding gums
 +
*[[vaginal Bleed Non-Pregnant|Menometrorrhagia]]
 +
*Easy bruising/[[petechiae]]
 +
*[[Hematuria]]
 +
 
==Differential Diagnosis==
 
==Differential Diagnosis==
===Increased Bleeding===
+
{{Increased bleeding DDX}}
*Platelet Related
 
**Too few
 
***[[Thrombocytopenia]]
 
**Nonfunctional
 
***Aspirin
 
*Factor Related
 
**Aquired
 
***Drug Related
 
****[[Warfarin (Coumadin)]]
 
****[[Unfractionated Heparin]]
 
****[[Low Molecular Weight Heparin (Enoxaparin)]] (i.e. Lovenox)
 
***Illness induced
 
****[[Vitamin K Deficiency]]
 
****[[DIC]]
 
****[[Liver Disease Induced Coagulopathy]]
 
****[[Renal Disease Induced Coagulopathy]]
 
**Genetic
 
***[[Hemophilia]]
 
***[[Factor VIII Inhibitor]]
 
***[[Lupus Anticoagulant]]
 
  
 
===Increased Clotting===
 
===Increased Clotting===
 +
*[[Disseminated Intravascular Coagulation (DIC)]]
  
==Managment==
+
==Management==
 
*[[Bleeding Treatments]]
 
*[[Bleeding Treatments]]
 
*[[Procedures in patients with coagulopathies]]
 
*[[Procedures in patients with coagulopathies]]
*[[Warfarin (Coumadin) Reversal]]
+
*[[Anticoagulant reversal]] (known medications)
*[[Dabigatran (Pradaxa) Reversal]]
+
**[[Warfarin (Coumadin) Reversal]]
 +
**[[Dabigatran (Pradaxa) Reversal]]
 +
**[[Rivaroxaban reversal]]
 +
**[[Unfractionated heparin reversal]]
 +
*[[Anti-platelet agent reversal]]
  
 
==See Also==
 
==See Also==
 
*[[Transfusions]]
 
*[[Transfusions]]
 +
*[[Idarucizumab]]
  
==Source==
+
==References==
*Tintinalli
+
<references/>
*UpToDate
 
 
 
 
[[Category:Heme/Onc]]
 
[[Category:Heme/Onc]]

Latest revision as of 00:16, 1 October 2019

Background

  • Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
  • Secondary hemostasis: coagulation cascade
Coagulation cascade

Clinical Features

Differential Diagnosis

Coagulopathy

Platelet Related

Factor Related

Increased Clotting

Management

See Also

References