Coagulopathy (main): Difference between revisions
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==Background== | |||
*Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug | |||
*Secondary hemostasis: coagulation cascade | |||
[[File:Coagulation cascade.png|thumbnail|Coagulation cascade]] | |||
==Clinical Features== | |||
*Spontaneous [[hemorrhage|bleeding]] | |||
*Bleeding out of proportion | |||
*Swollen joints | |||
*[[Epistaxis]] | |||
*Bleeding gums | |||
*[[vaginal Bleed Non-Pregnant|Menometrorrhagia]] | |||
*Easy bruising/[[petechiae]] | |||
*[[Hematuria]] | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Increased bleeding DDX}} | |||
===Increased Clotting=== | ===Increased Clotting=== | ||
*[[Disseminated Intravascular Coagulation (DIC)]] | |||
== | ==Management== | ||
*[[Bleeding Treatments]] | *[[Bleeding Treatments]] | ||
*[[Procedures in patients with coagulopathies]] | *[[Procedures in patients with coagulopathies]] | ||
*[[Warfarin (Coumadin) Reversal]] | *[[Anticoagulant reversal]] (known medications) | ||
*[[Dabigatran (Pradaxa) Reversal]] | **[[Warfarin (Coumadin) Reversal]] | ||
**[[Dabigatran (Pradaxa) Reversal]] | |||
**[[Rivaroxaban reversal]] | |||
**[[Unfractionated heparin reversal]] | |||
*[[Anti-platelet agent reversal]] | |||
==See Also== | ==See Also== | ||
*[[Transfusions]] | *[[Transfusions]] | ||
*[[Idarucizumab]] | |||
== | ==References== | ||
<references/> | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 00:16, 1 October 2019
Background
- Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
- Secondary hemostasis: coagulation cascade
Clinical Features
- Spontaneous bleeding
- Bleeding out of proportion
- Swollen joints
- Epistaxis
- Bleeding gums
- Menometrorrhagia
- Easy bruising/petechiae
- Hematuria
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Increased Clotting
Management
- Bleeding Treatments
- Procedures in patients with coagulopathies
- Anticoagulant reversal (known medications)
- Anti-platelet agent reversal