Difference between revisions of "Coagulopathy (main)"

 
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==DDX==
+
==Background==
*Aquired
+
*Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
**Drug Related
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*Secondary hemostasis: coagulation cascade
***[[Warfarin (Coumadin)]]
+
[[File:Coagulation cascade.png|thumbnail|Coagulation cascade]]
***[[Unfractionated Heparin]]
 
***[[Low Molecular Weight Heparin]]
 
**Illness induced
 
***[[Vitamin K Deficiency]]
 
***[[DIC]]
 
***[[Liver Disease Induced Coagulopathy]]
 
***[[Renal Disease Induced Coagulopathy]]
 
*Genetic
 
**[[Hemophilia]]
 
**[[Factor VIII Inhibitor]]
 
**[[Lupus Anticoagulant]]
 
  
==Managment==
+
==Clinical Features==
 +
*Spontaneous [[hemorrhage|bleeding]]
 +
*Bleeding out of proportion
 +
*Swollen joints
 +
*[[Epistaxis]]
 +
*Bleeding gums
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*[[vaginal Bleed Non-Pregnant|Menometrorrhagia]]
 +
*Easy bruising/[[petechiae]]
 +
*[[Hematuria]]
 +
 
 +
==Differential Diagnosis==
 +
{{Increased bleeding DDX}}
 +
 
 +
===Increased Clotting===
 +
*[[Disseminated Intravascular Coagulation (DIC)]]
 +
 
 +
==Management==
 
*[[Bleeding Treatments]]
 
*[[Bleeding Treatments]]
*[[Procedures in Patients with Coagulopathies]]
+
*[[Procedures in patients with coagulopathies]]
*[[Warfarin (Coumadin) Reversal]]
+
*[[Anticoagulant reversal]] (known medications)
*[[Dabigatran (Pradaxa) Reversal]]
+
**[[Warfarin (Coumadin) Reversal]]
 +
**[[Dabigatran (Pradaxa) Reversal]]
 +
**[[Rivaroxaban reversal]]
 +
**[[Unfractionated heparin reversal]]
 +
*[[Anti-platelet agent reversal]]
  
 
==See Also==
 
==See Also==
 +
*[[Transfusions]]
 +
*[[Idarucizumab]]
  
==Source==
+
==References==
*Tintinalli
+
<references/>
*UpToDate
 
 
 
 
[[Category:Heme/Onc]]
 
[[Category:Heme/Onc]]

Latest revision as of 00:16, 1 October 2019

Background

  • Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
  • Secondary hemostasis: coagulation cascade
Coagulation cascade

Clinical Features

Differential Diagnosis

Coagulopathy

Platelet Related

Factor Related

Increased Clotting

Management

See Also

References