Difference between revisions of "Coagulopathy (main)"
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| − | == | + | ==Background== |
| − | * | + | *Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug |
| − | * | + | *Secondary hemostasis: coagulation cascade |
| − | + | [[File:Coagulation cascade.png|thumbnail|Coagulation cascade]] | |
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| − | == | + | ==Clinical Features== |
| + | *Spontaneous [[hemorrhage|bleeding]] | ||
| + | *Bleeding out of proportion | ||
| + | *Swollen joints | ||
| + | *[[Epistaxis]] | ||
| + | *Bleeding gums | ||
| + | *[[vaginal Bleed Non-Pregnant|Menometrorrhagia]] | ||
| + | *Easy bruising/[[petechiae]] | ||
| + | *[[Hematuria]] | ||
| + | |||
| + | ==Differential Diagnosis== | ||
| + | {{Increased bleeding DDX}} | ||
| + | |||
| + | ===Increased Clotting=== | ||
| + | *[[Disseminated Intravascular Coagulation (DIC)]] | ||
| + | |||
| + | ==Management== | ||
*[[Bleeding Treatments]] | *[[Bleeding Treatments]] | ||
| − | *[[Warfarin (Coumadin) Reversal]] | + | *[[Procedures in patients with coagulopathies]] |
| + | *[[Anticoagulant reversal]] (known medications) | ||
| + | **[[Warfarin (Coumadin) Reversal]] | ||
| + | **[[Dabigatran (Pradaxa) Reversal]] | ||
| + | **[[Rivaroxaban reversal]] | ||
| + | **[[Unfractionated heparin reversal]] | ||
| + | *[[Anti-platelet agent reversal]] | ||
==See Also== | ==See Also== | ||
| + | *[[Transfusions]] | ||
| + | *[[Idarucizumab]] | ||
| − | + | ==References== | |
| − | == | + | <references/> |
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[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 00:16, 1 October 2019
Contents
Background
- Primary hemostasis: damage to endothelial basement membrane and formation of platelet plug
- Secondary hemostasis: coagulation cascade
Clinical Features
- Spontaneous bleeding
- Bleeding out of proportion
- Swollen joints
- Epistaxis
- Bleeding gums
- Menometrorrhagia
- Easy bruising/petechiae
- Hematuria
Differential Diagnosis
Coagulopathy
Platelet Related
- Too few
- Nonfunctional
Factor Related
- Acquired (Drug Related)
- Warfarin (Coumadin)
- Unfractionated heparin
- Low molecular weight heparin (i.e. enoxaparin (Lovenox), dalteparin)
- Factor Xa Inhibitors (e.g. rivaroxaban, apixaban, fondaparinux, edoxaban)
- Direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin)
- Illness induced
- Genetic
Increased Clotting
Management
- Bleeding Treatments
- Procedures in patients with coagulopathies
- Anticoagulant reversal (known medications)
- Anti-platelet agent reversal