Cloxacillin: Difference between revisions
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Upper Respiratory Tract Infection=== | |||
*>=1 yr to 18 yrs: 50-100 mg/kg/day orally divided every 6 hrs, Max dose 4g/day | |||
===Soft tissue and skin infection === | |||
*>=1 yr to 18 yrs: 50-100 mg/kg/day orally divided every 6 hrs, Max dose 4g/day | |||
==Special Populations== | ==Special Populations== |
Revision as of 02:08, 7 February 2016
General
- Type: Beta lactamase resistant penicillins
- Dosage Forms: 125 mg/5 ml oral powder, 250 mg, 500 mg
- Common Trade Names: Cloxapen, Dry Clox, Tegopen
Adult Dosing
Upper Respiratory Tract Infection
- 250 mg PO q6hrs for 7-14 days
Pneumonia
- 500 mg PO q6hrs for up to 21 days
Soft tissue/skin infection
- 500 mg PO q6hrs for 7 days or until 3 days after acute inflammation resolves
Pediatric Dosing
Upper Respiratory Tract Infection
- >=1 yr to 18 yrs: 50-100 mg/kg/day orally divided every 6 hrs, Max dose 4g/day
Soft tissue and skin infection
- >=1 yr to 18 yrs: 50-100 mg/kg/day orally divided every 6 hrs, Max dose 4g/day
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
Source
- ↑ Sanford Guide to Antimicrobial Therapy 2014