Clotrimazole: Difference between revisions

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==Administration==
==Administration==
*Type: Anti-fungal, azole
*Type: [[Antifungal]], azole
*Dosage Forms
*Dosage Forms
**Topical:1% cream
**Topical:1% cream
**Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
**Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
**Oropharyngeal: 10 mg troche
**Oropharyngeal: 10mg troche
*Routes of Administration: topical, oropharyngeal, vaginal
*Routes of Administration: topical, oropharyngeal, vaginal
*Common Trade Names
*Common Trade Names
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**Tinea
**Tinea
***Apply bid
***Apply bid
***2-4 wks for best results with corporis, cruris, pedis, versicolor
***2-4 weeks for best results with corporis, cruris, pedis, versicolor
*Vulvovaginal
*Vulvovaginal
**candidiasis, vulvovaginal
**candidiasis, vulvovaginal
***200 mg PV qhs x3 days
***200mg PV qhs x3 days
***Alt: 100 mg PV qhs x7 days
***Alt: 100mg PV qhs x7 days
***Alt: 1 applicatorful 2% PV qhs x3 days
***Alt: 1 applicatorful 2% PV qhs x3 days
***Alt: 1 applicatorful 1% PV qhs x7-14 days
***Alt: 1 applicatorful 1% PV qhs x7-14 days
*Oropharyngeal
*Oropharyngeal
**candidiasis tx, oropharyngeal
**candidiasis treatment, oropharyngeal
***10 mg PO 5x/day x14 days
***10mg PO 5x/day x14 days
****slowly dissolve in mouth; do not chew or swallow whole
****slowly dissolve in mouth; do not chew or swallow whole
**candidiasis prophylaxis, oropharyngeal
**candidiasis prophylaxis, oropharyngeal
***10 mg PO tid
***10mg PO tid
****continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole
****continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole
==Pediatric Dosing==
==Pediatric Dosing==
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<references/>
<references/>
[[Category:Pharmacology]]
[[Category:Pharmacology]]
[[Category:ID]]

Revision as of 17:44, 20 September 2019

Administration

  • Type: Antifungal, azole
  • Dosage Forms
    • Topical:1% cream
    • Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
    • Oropharyngeal: 10mg troche
  • Routes of Administration: topical, oropharyngeal, vaginal
  • Common Trade Names
    • Topical: Anti-Fungal Liquid, Desenex AF Prescription Strength, FungiCURE Pump Spray, Lotrimin AF Cream, Lotrimin AF For Her, Lotrimin AF Jock Itch, Lotrimin AF Solution, Lotrimin Jock Itch Powder, MPM Anti-Fungal, Prescription Strength Cruex
    • Vulvovaginal: Clotrimazole-3, Clotrimazole-7, Femcare, Gyne-Lotrimin, Gyne-Lotrimin 3 Day, Gyne-Lotrimin Combo Pack
    • Oropharyngeal: Mycelex Troche

Adult Dosing

  • Topical
    • Candidiasis, cutaneous
      • Apply bid
    • Tinea
      • Apply bid
      • 2-4 weeks for best results with corporis, cruris, pedis, versicolor
  • Vulvovaginal
    • candidiasis, vulvovaginal
      • 200mg PV qhs x3 days
      • Alt: 100mg PV qhs x7 days
      • Alt: 1 applicatorful 2% PV qhs x3 days
      • Alt: 1 applicatorful 1% PV qhs x7-14 days
  • Oropharyngeal
    • candidiasis treatment, oropharyngeal
      • 10mg PO 5x/day x14 days
        • slowly dissolve in mouth; do not chew or swallow whole
    • candidiasis prophylaxis, oropharyngeal
      • 10mg PO tid
        • continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole

Pediatric Dosing

Same as adult

Special Populations

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult: Precaution with troches. Monitor LFTs.
  • Pediatric:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

may occur but none reported

Common

  • Topical
    • irritation
    • burning/stinging
    • pruritus
    • erythema
    • localized edema
    • urticaria
    • peeling
    • blistering
  • Vulvovaginal
    • vulvovaginal burning
    • vulvovaginal pruritus
    • vulvovaginal soreness
    • vulvovaginal swelling
    • pelvic pain
    • pelvic cramps
    • abdominal pain
  • Oropharyngeal
    • vomiting
    • nausea
    • abdominal cramps
    • abnormal LFTs

Pharmacology

  • Half-life: Unknown
  • Metabolism: liver; CYP450: unknown; Info: minimal systemic absorption
  • Excretion: bile/feces primarily, urine

Mechanism of Action

  • Exact mechanism of action unknown
  • Azole antifungal
    • Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis and increasing cellular permeability

Comments

See Also

References