Clopidogrel: Difference between revisions

(Text replacement - "== " to "==")
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*caution if elective surgery w/in 5 days
*caution if elective surgery w/in 5 days
*caution if GI disorder
*caution if GI disorder
*caution if ocular dz
*caution if ocular disease
*caution if poor or intermediate CYP2C19 metabolizer
*caution if poor or intermediate CYP2C19 metabolizer
*caution if renal impairment, mod-severe
*caution if renal impairment, mod-severe

Revision as of 07:51, 13 July 2016

General

  • Type: Antiplatelet
  • Dosage Forms: 75, 300 PO
  • Common Trade Names: Plavix

Adult Dosing

Acute coronary syndrome

Thrombotic event prevention

  • 75 mg PO qd

Pediatric Dosing

  • Not Recommended

Special Populations

  • Pregnancy Rating: B
  • Lactation: Safety Unknown
  • Renal Dosing
    • Adult: not defined
    • Pediatric
  • Hepatic Dosing
    • Adult: no adjustment
    • Pediatric

Contraindications

  • Allergy to class/drug
  • active bleeding
  • caution if trauma
  • caution if elective surgery w/in 5 days
  • caution if GI disorder
  • caution if ocular disease
  • caution if poor or intermediate CYP2C19 metabolizer
  • caution if renal impairment, mod-severe

Adverse Reactions

Serious

Common

  • bleeding
  • pruritus

Pharmacology

  • Half-life: 8h
  • Metabolism: liver, CYP450: 1A2, 2C9, 2C19 (primary), 3A4 substrate
  • Excretion: urine 50%, feces 46%
  • Mechanism of Action: irreversibly binds to P2Y12 adenosine diphosphate receptors, reducing platelet activation and aggregation

See Also

References