Clonidine toxicity

Background

• Alpha-2 and opioid receptor agonist

Clinical Features

• Cardiac
  • Bradycardia
  • Hypotension
• Neuro
  • Lethargy (may progress to apnea)
  • Miotic pupils

Treatment

• Respiratory/neuro depression
  • Naloxone
    • High dose may be required (up to 10mg)
    • Not always effective
• Bradycardia
  • Atropine
• Hypotension
  • IVF

Source

• Tintinalli

See Also

Toxicology (Main)