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  • Type: Antipsychotic, first generation
  • Dosage Forms: 25mg/mL IV solution; 25mg/5 mL oral solution; 10, 25, and 100mg tablets
  • Routes of Administration: PO, IM, IV
  • Common Trade Names: Thorazine

Adult Dosing


  • Oral: 10 to 25mg every 4 to 6 hours as needed. May increase, if necessary.
  • IM: 25mg one time. If no hypotension occurs, give 25 to 50mg every 3 to 4 hours as needed, then switch to oral dosage.
  • IV: 2mg at 2 minute intervals. Do not exceed 25mg. Dilute to 1mg/mL.


  • Oral: 25 to 50mg 3 to 4 times a day
  • IM: If symptoms persist for 2 to 3 days, give 25 to 50mg IM
  • IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50mg in 500 to 1000 mL of saline.


  • IM: Initial Dose 25 to 50mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
  • Oral: Initial Dose: 10 to 25mg orally 3 times a day. Total daily doses should be increased in 20 to 50mg increments every 3 or 4 days until symptoms are controlled.
  • Usual Maintenance Dose: 200mg/day orally

Pediatric Dosing

should not be used in children under 6 months


  • Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed.
  • IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours

Maximum recommended doses

  • less than 5 years (less than 22.7 kg): 40mg/day
  • 5 and older (22.7-45.5 kg): 75mg/day

Special Populations



  • Allergy to class/drug

Adverse Reactions

  • Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

See Also


  1. Chlorpromazine. Retrieved from
  2. US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from
  3. P Young. The ICU Drug Manual. Chlorpromazine. Retrieved from