Chlorhexidine

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Administration

  • Type: Antiseptic
  • Dosage Forms: Liquid, powder
  • Routes of Administration: Topical
  • Common Trade Names: Betasept, Chlorostat


  • Commonly used for skin disinfection
  • Antimicrobial activity lasts up to six hours

Adult Dosing

Pediatric Dosing

Special Populations

Pregnancy Rating

Lactation risk

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:

Mechanism of Action

  • Chlorhexidine cation binds to negatively charged bacterial cell wall
  • Bacteriostatic at low concentrations, bacteriocidal at high concentrations

Comments

  • CLABSI risk lowest when chlorhexidine allowed to dry for two minutes after application prior to placing central line

See Also

References